APOE Alleles and Extreme Human Longevity

被引：91

作者：

Sebastiani, Paola ^{[1
]}

Gurinovich, Anastasia ^{[1
,2
]}

Nygaard, Marianne ^{[3
,4
]}

Sasaki, Takashi ^{[5
]}

Sweigart, Benjamin ^{[1
]}

Bae, Harold ^{[6
]}

Andersen, Stacy L. ^{[7
,8
]}

Villa, Francesco ^{[9
]}

Atzmon, Gil ^{[10
,11
]}

Christensen, Kaare ^{[3
,4
]}

Arai, Yasumichi ^{[5
]}

Barzilai, Nir ^{[11
]}

Puca, Annibale ^{[9
,12
]}

Christiansen, Lene ^{[3
,4
]}

Hirose, Nobuyoshi ^{[5
]}

Perls, Thomas T. ^{[7
,8
]}

机构：

[1] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA

[2] Boston Univ, Bioinformat Program, Boston, MA 02215 USA

[3] Univ Southern Denmark, Danish Aging Res Ctr, Odense, Denmark

[4] Univ Southern Denmark, Danish Twin Registry Epidemiol Biostat & Biodemog, Dept Publ Hlth, Odense, Denmark

[5] Keio Univ, Ctr Supercentenarian Res, Tokyo, Japan

[6] Oregon State Univ, Coll Publ Hlth & Human Sci, Corvallis, OR 97331 USA

[7] Boston Univ, Sch Med, Dept Med, Geriatr Sect, Boston, MA 02118 USA

[8] Boston Med Ctr, Boston, MA 02118 USA

[9] IRCCS MultiMed, Cardiovasc Res Unit, Milan, Italy

[10] Univ Haifa, Fac Nat Sci, Haifa, Israel

[11] Albert Einstein Coll Med, Dept Med & Genet, Bronx, NY 10467 USA

[12] Univ Salerno, Dept Med & Surg, Baronissi, Italy

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2019年 / 74卷 / 01期

基金：

美国国家卫生研究院;

关键词：

APOE; Extreme human longevity; Genetic association; Survival distribution; ALZHEIMERS-DISEASE PATIENTS; GENOME-WIDE ASSOCIATION; APOLIPOPROTEIN-E GENE; LIFE-SPAN; EXCEPTIONAL LONGEVITY; SURVIVAL; RISK; CENTENARIANS; COMPRESSION; MORTALITY;

D O I：

10.1093/gerona/gly174

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

We assembled a collection of 28,297 participants from seven studies of longevity and healthy aging comprising New England Centenarian, Long Life Family, Longevity Gene Population, Southern Italian Centenarian, Japanese Centenarian, the Danish Longevity, and the Health and Retirement Studies to investigate the association between the APOE alleles </mml:math> but with only a modest reduction in risk for death beyond an age reached by less than 1% of the population.

引用

页码：44 / 51

页数：8

共 53 条

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