Fluorous chiral bis(oxazolines): Synthesis and application in asymmetric Henry reaction

被引：22

作者：

Deng, Tao ^{[1
]}

Cai, Chun ^{[1
]}

机构：

[1] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing, Jiangsu, Peoples R China

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2013年 / 156卷

关键词：

Fluorous bis(oxazolines); Malononitrile; Henry reaction; Asymmetric catalysis; COPPER-CATALYSTS; LIGANDS; COMPLEXES;

D O I：

10.1016/j.jfluchem.2013.09.014

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A fluorous bis(oxazolines) was synthesized by a facile two-step process using malononitrile as the starting material. The compound was tested as a chiral ligand in copper-catalyzed Henry reactions of nitromethane with different aldehydes to afford the corresponding beta-nitroalcohols in 61-75% yield with enantioselectivities up to 99%. Furthermore, the fluorous ligand can be easily recovered and reused without significant loss in its activity. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：183 / 186

页数：4

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