Microstructural correlates of Edinburgh Cognitive and Behavioural ALS Screen (ECAS) changes in amyotrophic lateral sclerosis

被引:17
作者
Trojsi, Francesca [1 ]
Caiazzo, Giuseppina [1 ]
Siciliano, Mattia [1 ,2 ]
Femiano, Cinzia [1 ]
Passaniti, Carla [1 ,2 ]
Russo, Antonio [1 ]
Bisecco, Alvino [1 ]
Monsurro, Maria Rosaria [1 ]
Cirillo, Mario [1 ]
Esposito, Fabrizio [3 ]
Tedeschi, Gioacchino [1 ]
Santangelo, Gabriella [2 ]
机构
[1] Univ Campania Luigi Vanvitelli, MRI Res Ctr SUN FISM, Dept Adv Med & Surg Sci, Pzza Miraglia 2, I-80138 Naples, Italy
[2] Univ Campania Luigi Vanvitelli, Dept Psychol, Caserta, Italy
[3] Univ Salerno, Dept Med Surg & Dent, Scuola Med Salernitana, Salerno, Italy
关键词
Amyotrophic lateral sclerosis; Diffusion tensor imaging; TBSS; Frontotemporal dysfunction; Edinburgh Cognitive and Behavioural ALS; Screen; MOTOR-NEURON DISEASE; EXECUTIVE DYSFUNCTION; MEMORY DEFICITS; VERBAL FLUENCY; TEMPORAL-LOBE; TRACT; MRI; IMPAIRMENT; VALIDATION; RETRIEVAL;
D O I
10.1016/j.pscychresns.2019.04.001
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Edinburgh Cognitive and Behavioural ALS Screen (ECAS) was designed for testing patients with amyotrophic lateral sclerosis (ALS), a multi-system neurodegenerative disease characterized by progressive physical disability. In this study, we aim to explore the potential brain microstructural substrates associated with performance on ECAS in the early stages of ALS, using a whole-brain tract-based spatial statistics diffusion tensor imaging approach. Thirty-six non-demented ALS patients, assessed using ECAS, and 35 age-, sex- and education-matched healthy controls underwent magnetic resonance imaging at 3 Tesla. The ALS patients showed decreased fractional anisotropy (FA) in the cortico-spinal tracts and corpus callosum (CC) and significant association between verbal fluency score, among ALS-specific ECAS scores, and FA measures in several long association fiber tracts in the frontal, temporal and parietal lobes. Furthermore, the ALS non-specific total score was inversely related to axial diffusivity (AD) in the mediodorsal nucleus of the thalamus, with more extended areas of correlation in the CC, when considering only the memory subscore. Our results point towards microstructural degeneration across motor and extra-motor areas in ALS, underlining that alterations in verbal fluency performances may be related to impairment of frontotemporal connectivity, while alterations of memory may be associated with damage of thalamocortical circuits.
引用
收藏
页码:67 / 75
页数:9
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