Comparative genetics of MHC polymorphisms in different primate species: Duplications and deletions

被引:66
作者
Bontrop, RE [1 ]
机构
[1] Biomed Primate Res Ctr, Dept Comparat Genet & Refinement, NL-2280 GH Rijswijk, Netherlands
基金
美国国家卫生研究院;
关键词
D O I
10.1016/j.humimm.2006.03.007
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Gene products of the major histocompatibility complex (MHC) play a crucial role in the activation of adaptive (antigen-dependent) immune responses. In this paper similarities and dissimilarities among the MHCs of different primate species and their functional implications are reviewed. The human HLA system represents the most thoroughly investigated MHC of any contemporary living primate species, and so it will serve as a reference.
引用
收藏
页码:388 / 397
页数:10
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