Warfare and defense: The host response to Cryptococcus infection

被引：4
作者：
Dutra, Fabianno F. [1 ]
Albuquerque, Priscila C. [2 ]
Rodrigues, Marcio L. [2 ,3 ]
Fonseca, Fernanda L. [2 ]
机构：
[1] Univ Fed Rio de Janeiro, Inst Microbiol Paulo de Goes, Lab Inflamacao & Imunidade, Dept Imunol, Rio de Janeiro, Brazil
[2] Fundacao Oswaldo Cruz Fiocruz, CDTS, Rio De Janeiro, Brazil
[3] Univ Fed Rio de Janeiro, Dept Microbiol Geral, Inst Microbiol, Rio de Janeiro, Brazil
来源：
FUNGAL BIOLOGY REVIEWS | 2018年 / 32卷 / 02期
关键词：
Cryptococcus gattii; Cryptococcal infection; Cryptococcus neoformans; Host immunity; Immune response; Macrophage; COLONY-STIMULATING FACTOR; NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA; DENDRITIC CELL MATURATION; ALTERNATIVELY ACTIVATED MACROPHAGES; IMMUNE RECONSTITUTION SYNDROME; REGULATORY T-CELLS; PULMONARY INFECTION; NEOFORMANS INFECTION; NK CELLS;
D O I：
10.1016/j.fbr.2017.09.002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Cryptococcus neoformans and Cryptococcus gatti are the etiological agents of cryptococcosis, a life-threatening mycosis affecting the central nervous system. Cryptococcal meningoencephalitis is the most fatal mycosis in AIDS patients, resulting almost 200 000 deaths annually. High cost, side effects and drug resistance are constant elements during treatment of cryptococcosis, encouraging the development of novel therapeutic strategies including immunomodulatory protocols. Thereby, to understand how the host responds to Cryptococcus is essential. In this review, we discuss the immune response against Cryptococcus and immunoevasion strategies. (C) 2017 British Mycological Society. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：35 / 51
页数：17
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