Acute myelogenous leukemia stem cells: From Bench to Bedside

被引：39

作者：

Rico, J. Felipe ^{[1
]}

Hassane, Duane C. ^{[2
]}

Guzman, Monica L. ^{[3
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Pediat, New York, NY 10065 USA

[2] Cornell Univ, Weill Med Coll, Div Hematol Oncol, Dept Med,Inst Computat Biomed, New York, NY 10065 USA

[3] Cornell Univ, Weill Med Coll, Div Hematol Oncol, Dept Med, New York, NY 10065 USA

来源：

CANCER LETTERS | 2013年 / 338卷 / 01期

关键词：

AML; Leukemia; LSC; Leukemia stem cell; Acute myelogenous leukemia; Therapies; Chemoresistance; ACUTE MYELOID-LEUKEMIA; NF-KAPPA-B; RECEPTOR-ALPHA CHAIN; PHASE-II TRIAL; HEMATOPOIETIC STEM; GEMTUZUMAB OZOGAMICIN; CONNECTIVITY MAP; PROGENITOR CELLS; EXPRESSION; APOPTOSIS;

D O I：

10.1016/j.canlet.2012.05.034

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite reaching remission with traditional chemotherapy, most adult patients with acute myeloid leukemia (AML) will relapse and die of their disease. Numerous studies have identified a rare subset of leukemia cells that evade traditional chemotherapy and are capable of self-renewal and initiating leukemia. These cells are thought to be responsible for relapse and are termed leukemia stem cells (LSCs). This article will review the current LSC translational research and focus on new approaches to detect LSC burden and its prognostic implications, as well as the identification and development of therapeutic agents active against LSCs. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：4 / 9

页数：6

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