Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition?

被引：166

作者：

Vivier, E ^{[1
]}

Tomasello, E ^{[1
]}

Paul, P ^{[1
]}

机构：

[1] Univ Aix Marseille 2, Ctr Immunol Marseille Luminy, CNRS, INSERM, F-13288 Marseille 09, France

来源：

CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 03期

关键词：

D O I：

10.1016/S0952-7915(02)00337-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

NKG2D is an activating cell surface receptor expressed on a wide range of immune effector cells including NK cells, NKT cells, gammadelta T cells as well as CD8(+) alphabeta T cells. Recent data indicate two major features: first, that human (MICA, MICB and ULBP) and mouse (Rae1 and H60) NKG2D ligands can be induced and/or upregulated upon cellular distress; and second, that on T cells NKG2D serves as a co-stimulation molecule for TCR triggering, whereas on NK cells NKG2D may act as a primary recognition structure.

引用

页码：306 / 311

页数：6

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