MiR-145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer

被引：115

作者：

Noh, Ji Heon ^{[1
,2
]}

Chang, Young Gyoon ^{[1
,2
]}

Kim, Min Gyu ^{[1
,2
]}

Jung, Kwang Hwa ^{[1
,2
]}

Kim, Jeong Kyu ^{[1
,2
]}

Bae, Hyun Jin ^{[1
,2
]}

Eun, Jung Woo ^{[1
,2
]}

Shen, Qingyu ^{[1
,2
]}

Kim, Seung-Jin ^{[1
,2
]}

Kwon, So Hee ^{[3
]}

Park, Won Sang ^{[1
]}

Lee, Jung Young ^{[1
,2
]}

Nam, Suk Woo ^{[1
,2
]}

机构：

[1] Catholic Univ Korea, Coll Med, Dept Pathol, Lab Oncogenom, Seoul 137701, South Korea

[2] Catholic Univ Korea, Funct RNom Res Ctr, Seoul 137701, South Korea

[3] Yonsei Univ, Yonsei Inst Pharmaceut Sci, Coll Pharm, Inchon 406840, South Korea

来源：

CANCER LETTERS | 2013年 / 335卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

MiR-145; HDAC2; Tumor suppressor; Liver cancer; INCREASED EXPRESSION; MICRORNAS; GENE; STRATEGIES; INDUCTION; GROWTH; HDACS;

D O I：

10.1016/j.canlet.2013.03.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aberrant regulation of histone deacetylase 2 (HDAC2) plays a pivotal role in the development of hepatocellular carcinoma (HCC), but, the underlying mechanism leading to HDAC2 overexpression is not well understood. We performed microRNA (miRNA) profiling analysis in a subset of HCCs, and identified four down-regulated miRNAs that may target HDAC2 in HCC. Ectopic expression of miRNA mimics evidenced that miR-145 suppresses HDAC2 expression in HCC cells. This treatment repressed cancer cell growth and recapitulated HDAC2 knockdown effects on HCC cells. In conclusion, we suggest that loss or suppression of miR-145 may cause aberrant overexpression of HDAC2 and promote HCC tumorigenesis. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：455 / 462

页数：8

共 29 条

[1] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[2] Histone deacetylase inhibitors as anti-neoplastic agents [J].

Batty, Nicolas ;

Malouf, Gabriel G. ;

Issa, Jean Pierre J. .

CANCER LETTERS, 2009, 280 (02) :192-200

[3] Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms [J].

Fernandes, I ;

Bastien, Y ;

Wai, T ;

Nygard, K ;

Lin, R ;

Cormier, O ;

Lee, HS ;

Eng, F ;

Bertos, NR ;

Pelletier, N ;

Mader, S ;

Han, VKM ;

Yang, XJ ;

White, JH .

MOLECULAR CELL, 2003, 11 (01) :139-150

[4] Deregulation of microRNA expression occurs early and accumulates in early stages of HBV-associated multistep hepatocarcinogenesis [J].

Gao, Peng ;

Wong, Carmen Chak-Lui ;

Tung, Edmund Kwok-Kwan ;

Lee, Joyce Man-Fong ;

Wong, Chun-Ming ;

Ng, Irene Oi-Lin .

JOURNAL OF HEPATOLOGY, 2011, 54 (06) :1177-1184

[5] microRNAs: Master Regulators as Potential Therapeutics in Cancer [J].

Garofalo, Michela ;

Croce, Carlo M. .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 51, 2011, 2011, 51 :25-43

[6] Targeting microRNAs in cancer: rationale, strategies and challenges [J].

Garzon, Ramiro ;

Marcucci, Guido ;

Croce, Carlo M. .

NATURE REVIEWS DRUG DISCOVERY, 2010, 9 (10) :775-789

[7] Histone deacetylases and cancer [J].

Glozak, M. A. ;

Seto, E. .

ONCOGENE, 2007, 26 (37) :5420-5432

[8] MicroRNA gene expression deregulation in human breast cancer [J].

Iorio, MV ;

Ferracin, M ;

Liu, CG ;

Veronese, A ;

Spizzo, R ;

Sabbioni, S ;

Magri, E ;

Pedriali, M ;

Fabbri, M ;

Campiglio, M ;

Ménard, S ;

Palazzo, JP ;

Rosenberg, A ;

Musiani, P ;

Volinia, S ;

Nenci, I ;

Calin, GA ;

Querzoli, P ;

Negrini, M ;

Croce, CM .

CANCER RESEARCH, 2005, 65 (16) :7065-7070

[9] Histone deacetylases and cancer: Causes and therapies [J].

Marks, PA ;

Rifkind, RA ;

Richon, VM ;

Breslow, R ;

Miller, T ;

Kelly, WK .

NATURE REVIEWS CANCER, 2001, 1 (03) :194-202

[10] MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer [J].

Meng, Fanyin ;

Henson, Roger ;

Wehbe-Janek, Hania ;

Ghoshal, Kalpana ;

Jacob, Samson T. ;

Patel, Tushar .

GASTROENTEROLOGY, 2007, 133 (02) :647-658

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