The State of Hepatitis B and C in the Mediterranean and Balkan Countries: Report from a Summit Conference

被引:57
作者
Hatzakis, A. [1 ]
Van Damme, P. [2 ]
Alcorn, K. [3 ]
Gore, C. [4 ]
Benazzouz, M. [5 ]
Berkane, S. [6 ]
Buti, M. [7 ]
Carballo, M. [8 ]
Cortes Martins, H. [9 ]
Deuffic-Burban, S. [10 ,11 ]
Dominguez, A. [12 ]
Donoghoe, M. [13 ]
Elzouki, A-N. [14 ,15 ]
Bouafif, N. Ben-Alaya [16 ]
Esmat, G. [17 ]
Esteban, R. [18 ]
Fabri, M. [19 ]
Fenton, K. [20 ]
Goldberg, D. [21 ]
Goulis, I. [22 ]
Hadjichristodoulou, T. [23 ]
Hatzigeorgiou, T. [24 ]
Hamouda, O. [25 ]
Hasurdjiev, S. [26 ]
Hughes, S. [24 ]
Kautz, A. [26 ]
Malik, M. [27 ]
Manolakopoulos, S. [28 ]
Maticic, M. [29 ]
Papatheodoridis, G. [30 ]
Peck, R. [31 ]
Peterle, A. [24 ]
Potamitis, G. [32 ]
Prati, D. [33 ]
Roudot-Thoraval, F. [34 ]
Reic, T. [26 ]
Sharara, A. [35 ]
Shennak, M. [36 ]
Shiha, G. [37 ]
Shouval, D. [38 ]
Socan, M. [39 ]
Thomas, H. [40 ]
Thursz, M. [40 ]
Tosti, M. [41 ]
Trepo, C. [42 ,43 ,44 ]
Vince, A. [45 ]
Vounou, E. [46 ]
Wiessing, L. [47 ]
Manns, M. [48 ]
机构
[1] Athens Univ Med Sch, Athens 11527, Greece
[2] Univ Antwerp, Viral Hepatitis Prevent Board, Vaccine & Infect Dis Inst, B-2020 Antwerp, Belgium
[3] NAM Publicat Infohep Org, London, England
[4] Hepatitis C Trust, London, England
[5] Ibn Sina Hosp, Rabat, Morocco
[6] Bologhine Hosp, Dept Med & Gastroenterol, Algiers, Algeria
[7] Hosp Univ Vall dHebron, Dept Internal Med, Barcelona, Spain
[8] Int Ctr Migrat Hlth & Dev, Geneva, Switzerland
[9] Inst Nacl Saude Dr Ricardo Jorge, Dept Doencas Infecciosas, Lisbon, Portugal
[10] Univ Lille Nord France, Inserm U995, Lille, France
[11] Univ Paris 07, U738, TIP AVENIR Inserm Modelisat Aide & Decis & Cout E, Paris, France
[12] Univ Barcelona, CIBERESP, Dept Salut Publ, Barcelona, Spain
[13] World Hlth Org Reg Off Europe, Copenhagen, Denmark
[14] HMC, Hamad Gen Hosp, Dept Med, Doha, Qatar
[15] Benghazi Univ, Fac Med, Benghazi, Libya
[16] Minist Hlth, Observ New & Emerging Dis, Tunis, Tunisia
[17] Cairo Univ, Fac Med, Endem Med & Hepatogastroenterol Dept, Cairo, Egypt
[18] Hosp Univ Vall dHebron, Internal Med & Liver Unit, Barcelona, Spain
[19] Clin Ctr Vojvodina, Clin Infect Dis, Novi Sad, Serbia
[20] Publ Hlth England, Hlth & Wellbeing Directorate, London, England
[21] Hlth Protect Scotland, Grp Blood Borne Viruses Sexually Transmitted Infe, Glasgow, Lanark, Scotland
[22] Aristotle Univ Thessaloniki, Dept Med 4, GR-54006 Thessaloniki, Greece
[23] Univ Thessaly, Dept Hyg & Epidemiol, Larisa, Greece
[24] European Parliament, Brussels, Belgium
[25] Robert Koch Inst, Dept Infect Dis Epidemiol, Berlin, Germany
[26] European Liver Patients Assoc, St Truiden, Belgium
[27] World Hlth Org Reg Off Eastern Mediterranean, Cairo, Egypt
[28] Hippokrateion Hosp, Athens Med Sch, Dept Gastroenterol, Athens, Greece
[29] Univ Med Ctr Ljubljana, Clin Infect Dis & Febrile Illnesses, Ljubljana, Slovenia
[30] Athens Univ Med Sch, Dept Internal Med 2, Athens 11527, Greece
[31] World Hepatitis Alliance, Geneva, Switzerland
[32] Pancyprian Med Assoc, Nicosia, Cyprus
[33] Osped Alessandro Manzoni, Dept Transfus Med & Hematol, Lecce, Italy
[34] Univ Paris Est Creteil, Hop Henri Mondor, AP HP, Dept Sante Publ, Creteil, France
[35] Amer Univ Med Ctr, Beirut, Lebanon
[36] Univ Jordan, Amman, Jordan
[37] Egyptian Liver Res Inst & Hosp, Cairo, Egypt
[38] Hadassah Hebrew Univ Hosp, Liver Unit, Jerusalem, Israel
[39] Natl Inst Publ Hlth, Ljubljana, Slovenia
[40] Univ London Imperial Coll Sci Technol & Med, London, England
[41] Natl Ctr Epidemiol Surveillance & Hlth Promot, Ist Super Sanita, Rome, Italy
[42] Hop Croix Rousse, Hosp Civils Lyon, Serv Hepatol, F-69317 Lyon, France
[43] CRCL INSERM U1052, Lyon, France
[44] Univ Lyon 1, F-69365 Lyon, France
[45] Croatian Referral Ctr Diagnost & Treatment Viral, Zagreb, Croatia
[46] Limassol Gen Hosp, Limassol, Cyprus
[47] European Monitoring Ctr Drugs & Drug Addict, Lisbon, Portugal
[48] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, Hannover, Germany
关键词
Balkan region; hepatitis B; hepatitis C; hepatocellular carcinoma; Mediterranean; northern Africa; surveillance; SUSTAINED VIROLOGICAL RESPONSE; INJECTING DRUG-USERS; VIRUS-INFECTION; RISK-FACTORS; INTRAFAMILIAL TRANSMISSION; COST-EFFECTIVENESS; HCV INFECTIONS; PREGNANT-WOMEN; HIV-INFECTION; PREVALENCE;
D O I
10.1111/jvh.12120
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The burden of disease due to chronic viral hepatitis constitutes a global threat. In many Balkan and Mediterranean countries, the disease burden due to viral hepatitis remains largely unrecognized, including in high-risk groups and migrants, because of a lack of reliable epidemiological data, suggesting the need for better and targeted surveillance for public health gains. In many countries, the burden of chronic liver disease due to hepatitis B and C is increasing due to ageing of unvaccinated populations and migration, and a probable increase in drug injecting. Targeted vaccination strategies for hepatitis B virus (HBV) among risk groups and harm reduction interventions at adequate scale and coverage for injecting drug users are needed. Transmission of HBV and hepatitis C virus (HCV) in healthcare settings and a higher prevalence of HBV and HCV among recipients of blood and blood products in the Balkan and North African countries highlight the need to implement and monitor universal precautions in these settings and use voluntary, nonremunerated, repeat donors. Progress in drug discovery has improved outcomes of treatment for both HBV and HCV, although access is limited by the high costs of these drugs and resources available for health care. Egypt, with the highest burden of hepatitis C in the world, provides treatment through its National Control Strategy. Addressing the burden of viral hepatitis in the Balkan and Mediterranean regions will require national commitments in the form of strategic plans, financial and human resources, normative guidance and technical support from regional agencies and research.
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页码:1 / 20
页数:20
相关论文
共 89 条
[1]   Genetic diversity in hepatitis C virus in Egypt and possible association with hepatocellular carcinoma [J].
Abdel-Hamid, Mohamed ;
El-Daly, Mai ;
Molnegren, Vilma ;
El-Kafrawy, Sherif ;
Abdel-Latif, Sohair ;
Esmat, Gamal ;
Strickland, G. Thomas ;
Loffredo, Christopher ;
Albert, Jan ;
Widell, Anders .
JOURNAL OF GENERAL VIROLOGY, 2007, 88 :1526-1531
[2]   HIGH SEROPREVALENCE OF HEPATITIS-C INFECTION AMONG RISK GROUPS IN EGYPT [J].
ABDELWAHAB, MF ;
ZAKARIA, S ;
KAMEL, M ;
ABDELKHALIQ, MK ;
MABROUK, MA ;
SALAMA, H ;
ESMAT, G ;
THOMAS, DL ;
STRICKLAND, GT .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1994, 51 (05) :563-567
[3]  
Ahmetagic Sead, 2006, Bosn J Basic Med Sci, V6, P13
[4]   Current progress in the treatment of chronic hepatitis C [J].
Alexopoulou, Alexandra ;
Papatheodoridis, George V. .
WORLD JOURNAL OF GASTROENTEROLOGY, 2012, 18 (42) :6060-6069
[5]  
[Anonymous], 2012, Prevention and control of viral hepatitis infection: framework for global action
[6]  
[Anonymous], STAT B 2010 DRUG REL
[7]  
[Anonymous], VACCINES
[8]  
[Anonymous], BLOOD SERVICES SE EU
[9]  
[Anonymous], J HEPATOL
[10]  
[Anonymous], 2012 ANN REP STAT DR