Dual-Channel Electrospray Microchip

被引：8
作者：
Lu, Yu [1 ]
Liu, Fang [1 ]
Lion, Niels [2 ]
Girault, Hubert H. [1 ]
机构：
[1] Ecole Polytech Fed Lausanne, Stn 6, Lab Electrochim Phys & Analyt, CH-1015 Lausanne, Switzerland
[2] Serv Reg Vaudois Transfus Sanguine, Epalinges, Switzerland
来源：
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | 2013年 / 24卷 / 03期
基金：
瑞士国家科学基金会;
关键词：
Dual-channel emitter; Microchip; Micro-electrospray ionization; Mass spectrometry; MASS-SPECTROMETRY; IONIZATION;
D O I：
10.1007/s13361-012-0547-z
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A dual-channel electrospray microchip has been developed for electrospray ionization mass spectrometry (ESI-MS) where aqueous samples are mixed at the Taylor cone with an organic buffer. Due to the fast and effective mixing in the Taylor cone, the aqueous sample can be well ionized with a high ion intensity. The influence of geometric parameters such as the distance between the two microchannels at their junction at the tip of the emitter has been investigated together with chemical parameters such as the organic buffer composition.
引用
收藏
页码：454 / 457
页数：4
相关论文
共 13 条
  • [1] Practical implications of some recent studies in electrospray ionization fundamentals
    Cech, NB
    Enke, CG
    [J]. MASS SPECTROMETRY REVIEWS, 2001, 20 (06) : 362 - 387
  • [2] MICRO-ELECTROSPRAY MASS-SPECTROMETRY - ULTRA-HIGH-SENSITIVITY ANALYSIS OF PEPTIDES AND PROTEINS
    EMMETT, MR
    CAPRIOLI, RM
    [J]. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 1994, 5 (07) : 605 - 613
  • [3] NANOELECTROSPRAY EMITTERS: TRENDS AND PERSPECTIVE
    Gibson, Graham T. T.
    Mugo, Samuel M.
    Oleschuk, Richard D.
    [J]. MASS SPECTROMETRY REVIEWS, 2009, 28 (06) : 918 - 936
  • [4] Gobry V, 2002, PROTEOMICS, V2, P405, DOI 10.1002/1615-9861(200204)2:4<405::AID-PROT405>3.0.CO
  • [5] 2-Y
  • [6] On-chip protein sample desalting and preparation for direct coupling with electrospray ionization mass spectrometry
    Lion, N
    Gellon, JO
    Jensen, H
    Girault, HH
    [J]. JOURNAL OF CHROMATOGRAPHY A, 2003, 1003 (1-2) : 11 - 19
  • [7] Peptide-Phospholipid Complex Formation at Liquid-Liquid Interfaces
    Mendez, Manuel A.
    Prudent, Michel
    Su, Bin
    Girault, Hubert H.
    [J]. ANALYTICAL CHEMISTRY, 2008, 80 (24) : 9499 - 9507
  • [8] In-Spray Supercharging of Peptides and Proteins in Electrospray Ionization Mass Spectrometry
    Miladinovic, Sasa M.
    Fornelli, Luca
    Lu, Yu
    Piech, Krzysztof M.
    Girault, Hubert H.
    Tsybin, Yury O.
    [J]. ANALYTICAL CHEMISTRY, 2012, 84 (11) : 4647 - 4651
  • [9] Biphasic Electrospray Ionization for the Study of Interfacial Complexes
    Prudent, Michel
    Mendez, Manuel A.
    Girault, Hubert H.
    [J]. ANALYTICAL SCIENCES, 2008, 24 (11) : 1399 - 1404
  • [10] Microfabricated dual sprayer for on-line mass tagging of phosphopeptides
    Prudent, Michel
    Rossier, Joel S.
    Lion, Niels
    Girault, Hubert H.
    [J]. ANALYTICAL CHEMISTRY, 2008, 80 (07) : 2531 - 2538
12