Neutrophils in viral infection

被引：94

作者：

Naumenko, Victor ^{[1
,2
]}

Turk, Madison ^{[1
]}

Jenne, Craig N. ^{[1
,3
]}

Kim, Seok-Joo ^{[1
,4
]}

机构：

[1] Univ Calgary, Calvin Phoebe & Joan Snyder Inst Chron Dis, Dept Microbiol Immunol & Infect Dis, HRIC 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada

[2] Natl Univ Sci & Technol MISIS, Leninskiy Prospect 4, Moscow 119991, Russia

[3] Univ Calgary, Calvin Phoebe & Joan Snyder Inst Chron Dis, Dept Microbiol Immunol & Infect Dis, HRIC 2C26,3280 Hosp Dr NW, Calgary, AB T2N 4N1, Canada

[4] Univ Calgary, Calvin Phoebe & Joan Snyder Inst Chron Dis, Dept Microbiol Immunol & Infect Dis, HRIC 4C49,3280 Hosp Dr NW, Calgary, AB T2N 4N1, Canada

来源：

CELL AND TISSUE RESEARCH | 2018年 / 371卷 / 03期

关键词：

Antiviral immunity; Neutrophils; Innate immunity; Virus; Oncolytic virus; HERPES-SIMPLEX-VIRUS; INFLUENZA-A VIRUS; POLYMORPHONUCLEAR LEUKOCYTES; ALVEOLAR MACROPHAGES; ANTIVIRAL ACTIVITY; DENDRITIC CELLS; INNATE IMMUNITY; TROJAN HORSE; BONE-MARROW; LUNG INJURY;

D O I：

10.1007/s00441-017-2763-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Neutrophils are the first wave of recruited immune cells to sites of injury or infection and are crucial players in controlling bacterial and fungal infections. Although the role of neutrophils during bacterial or fungal infections is well understood, their impact on antiviral immunity is much less studied. Furthermore, neutrophil function in tumor pathogenesis and cancer treatment has recently received much attention, particularly within the context of oncolytic virus infection where neutrophils produce antitumor cytokines and enhance oncolysis. In this review, multiple functions of neutrophils in viral infections and immunity are discussed. Understanding the role of neutrophils during viral infection may provide insight into the pathogenesis of virus infections and the outcome of virus-based therapies.

引用

页码：505 / 516

页数：12

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