Catalytic Asymmetric Cyclopropanation with Diazooxindole

被引：53

作者：

Awata, Atsuko ^{[1
]}

Arai, Takayoshi ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Sci, Dept Chem, Inage Ku, Chiba 2638522, Japan

来源：

SYNLETT | 2013年 / 24卷 / 01期

关键词：

asymmetric catalysis; spiro compounds; carbenoids; cyclopropanation; oxindole; HIGHLY ENANTIOSELECTIVE CYCLOPROPANATION; REVERSE-TRANSCRIPTASE INHIBITORS; SUBSTITUTED RHODIUM CARBENOIDS; BRYOZOAN AMATHIA-CONVOLUTA; ELECTRON-DEFICIENT OLEFINS; STRUCTURE-BASED DESIGN; H INSERTION REACTIONS; MAMMALIAN-CELL CYCLE; DIASTEREOSELECTIVE SYNTHESIS; CHIRAL LIGANDS;

D O I：

10.1055/s-0032-1317746

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first catalytic asymmetric cyclopropanation using styrene and diazooxindole was achieved with Rh-2(S-PTTL)(4). The reaction proceeded smoothly with 1 mol% catalyst loading to provide a good yield of the biologically important spiro-cyclopropyloxindole product with moderate to good enantioselectivity and excellent diastereoselectivity.

引用

页码：29 / 32

页数：4

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