Regulatory T Cells in Obesity

被引：10
|
作者：
Kucharska, Anna M. [1 ]
Pyrzak, Beata [1 ]
Demkow, Urszula [2 ]
机构：
[1] Med Univ Warsaw, Dept Pediat & Endocrinol, PL-00576 Warsaw, Poland
[2] Med Univ Warsaw, Dept Lab Diagnost & Clin Immunol Dev Age, PL-00576 Warsaw, Poland
来源：
NONCOMMUNICABLE DISEASES | 2015年 / 866卷
关键词：
Immune regulation; Insulin; Leptin; Obesity; Tregs; ADIPOSE-TISSUE; INSULIN-RESISTANCE; METABOLIC-DISORDERS; UNIQUE POPULATION; IMMUNE CELLS; KEY PLAYERS; LEPTIN; INFLAMMATION; INDUCTION; MICE;
D O I：
10.1007/5584_2015_147
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The current concept of the pathogenesis of obesity relates to the inflammation caused by excess of adipose tissue. Regulatory T cells accumulated in visceral adipose tissue (VAT-resident Tregs) are also involved in this pathogenesis. In the present paper the mechanisms responsible for alterations in the number and function of VAT-resident Tregs T in obesity are described. The role of Tregs in inflammation, insulin resistance, atherogenesis, and also the influence on VAT-resident Tregs of adipocytokines and insulin are reviewed.
引用
收藏
页码：35 / 40
页数：6
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