Regulatory T Cells in Obesity

被引：10

作者：

Kucharska, Anna M. ^{[1
]}

Pyrzak, Beata ^{[1
]}

Demkow, Urszula ^{[2
]}

机构：

[1] Med Univ Warsaw, Dept Pediat & Endocrinol, PL-00576 Warsaw, Poland

[2] Med Univ Warsaw, Dept Lab Diagnost & Clin Immunol Dev Age, PL-00576 Warsaw, Poland

来源：

NONCOMMUNICABLE DISEASES | 2015年 / 866卷

关键词：

Immune regulation; Insulin; Leptin; Obesity; Tregs; ADIPOSE-TISSUE; INSULIN-RESISTANCE; METABOLIC-DISORDERS; UNIQUE POPULATION; IMMUNE CELLS; KEY PLAYERS; LEPTIN; INFLAMMATION; INDUCTION; MICE;

D O I：

10.1007/5584_2015_147

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The current concept of the pathogenesis of obesity relates to the inflammation caused by excess of adipose tissue. Regulatory T cells accumulated in visceral adipose tissue (VAT-resident Tregs) are also involved in this pathogenesis. In the present paper the mechanisms responsible for alterations in the number and function of VAT-resident Tregs T in obesity are described. The role of Tregs in inflammation, insulin resistance, atherogenesis, and also the influence on VAT-resident Tregs of adipocytokines and insulin are reviewed.

引用

页码：35 / 40

页数：6

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