Soluble CD14 subtype (sCD14-ST) presepsin in critically ill preterm newborns: preliminary reference ranges

被引：44

作者：

Mussap, Michele ^{[1
]}

Puxeddu, Elisabetta ^{[2
,3
]}

Burrai, Patrizia ^{[2
,3
]}

Noto, Antonio ^{[2
,3
]}

Cibecchini, Francesco ^{[1
]}

Testa, Marcella ^{[2
,3
]}

Puddu, Melania ^{[2
,3
]}

Ottonello, Giovanni ^{[2
,3
]}

Dessi, Angelica ^{[2
,3
]}

Irmesi, Roberta ^{[2
,3
]}

Dalla Gassa, Elisabetta ^{[2
,3
]}

Fanni, Claudia ^{[2
,3
]}

Fanos, Vassilios ^{[2
,3
]}

机构：

[1] IRCCS Univ Hosp San Martino IST, Natl Inst Canc Res, Dept Lab Med, I-16132 Genoa, Italy

[2] Univ Cagliari, Sect Neonatal Intens Care Unit, Inst Puericulture, Dept Surg, Cagliari, Italy

[3] Univ Cagliari, Neonatal Sect, Cagliari, Italy

来源：

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE | 2012年 / 25卷

关键词：

Neonatal sepsis; preterm newborns; reference ranges; soluble CD14 subtype presepsin (sCD14-ST);

D O I：

10.3109/14767058.2012.717462

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Soluble CD14 subtype (sCD14-ST), also named presepsin, is a 13 kDa truncated form of soluble CD14 (sCD14), consisting of 64 amino acid residues. Systemic inflammation and sepsis are characterized by an early, significant increase in sCD14-ST presepsin blood concentration and thus, this small polypeptide has been proposed as a novel, reliable biomarker for the management of sepsis. We enrolled twenty-six consecutive non-septic preterm newborns with gestational age (GA) between 26 and 36 weeks) admitted to NICU after the first day of life for various severe diseases. sCD14-ST presepsin was measure on whole blood samples by a rapid commercial available chemiluminescent enzyme immunoassay (CLEIA) based on a non-competitive CLEIA. The mean sCD14-ST presepsin blood level in 26 preterm newborns was 643.1 ng/L, with a standard deviation (SD) of 303.8 ng/L; the median value was 578 ng/L. Our results clearly suggest no correlation between GA and sCD14-ST presepsin blood level between 26 and 36 weeks and thus it is reasonable to adopt a unique reference range for preterm newborns.

引用

页码：51 / 53

页数：3

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