What if stem cells turn into embryos in a dish?

被引：52

作者：

Pera, Martin F. ^{[1
,2
,3
]}

de Wert, Guido ^{[4
,5
]}

Dondorp, Wybo ^{[4
,5
]}

Lovell-Badge, Robin ^{[6
]}

Mummery, Christine L. ^{[7
]}

Munsie, Megan ^{[1
]}

Tam, Patrick P. ^{[8
,9
]}

机构：

[1] Univ Melbourne, Dept Anat & Neurosci, Melbourne, Vic, Australia

[2] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

[3] Florey Neurosci & Mental Hlth Inst, Parkville, Vic, Australia

[4] Maastricht Univ, Res Sch Care & Publ Hlth Res Inst, Dept Hlth Eth & Soc, NL-6200 MD Maastricht, Netherlands

[5] Maastricht Univ, GROW Sch Oncol & Dev Biol, NL-6200 MD Maastricht, Netherlands

[6] Francis Crick Inst, London, England

[7] Leiden Univ, Med Ctr, Dept Anat & Embryol, Leiden, Netherlands

[8] Childrens Med Res Inst, Embryol Unit, Westmead, NSW, Australia

[9] Univ Sydney, Sydney Med Sch, Discipline Med, Sydney, NSW 2006, Australia

来源：

NATURE METHODS | 2015年 / 12卷 / 10期

基金：

英国医学研究理事会;

关键词：

FATE;

D O I：

10.1038/nmeth.3586

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies show that pluripotent stem cells can undergo self-organized development in vitro into structures that mimic the body plan of the post-implantation embryo. Modeling human embryogenesis in a dish opens up new possibilities for the study of early development and developmental disorders, but it may also raise substantial ethical concerns. © 2015 Nature America, Inc. All rights reserved.

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收藏

页码：917 / 919

页数：3

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