Effects of cerebellar dentate nucleus GABAergic cells on rat inferior olivary neurons

被引：9
|
作者：
Garifoli, A [1 ]
Scardilli, G [1 ]
Perciavalle, V [1 ]
机构：
[1] Univ Catania, Dept Physiol Sci, I-95125 Catania, Italy
来源：
NEUROREPORT | 2001年 / 12卷 / 17期
关键词：
cerebellum; GABA; inferior olive; motor control;
D O I：
10.1097/00001756-200112040-00021
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The present study was undertaken to analyze the effects on unitary activity of inferior olive (IO) neurons elicited by activation of cerebellar lateral nucleus (LN), in rats submitted to the chronic destruction of MDJ structures, i.e. in animals in which the LN-evoked effects in IO should be depended only on activation of GABAergic cells of LN. It has been observed that about two-thirds of the olivocerebellar neurons are significantly affected by LN stimulation, and >68% of those cells were inhibited. Two-thirds of the inhibitory responses were compatible with a monosynaptic linkage, whereas the remaining inhibitions were probably due to polisynaptic linkages. The majority of LN-induced inhibitions was abolished or greatly reduced following application of GABA antagonists. NeuroReport 12:3709-3713 (C) 2001 Lippincott Williams & Wilkins.
引用
收藏
页码：3709 / 3713
页数：5
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