Oxidative Stress and the Microbiota-Gut-Brain Axis

被引：171

作者：

Dumitrescu, Laura ^{[1
,2
]}

Popescu-Olaru, Iulia ^{[1
,2
]}

Cozma, Liviu ^{[1
,2
]}

Tulba, Delia ^{[1
,2
]}

Hinescu, Mihail Eugen ^{[3
,4
]}

Ceafalan, Laura Cristina ^{[3
,4
]}

Gherghiceanu, Mihaela ^{[3
,4
]}

Popescu, Bogdan Ovidiu ^{[1
,2
,4
]}

机构：

[1] Carol Davila Univ Med & Pharm, Dept Clin Neurosci, 37 Dionisie Lupu Str, Bucharest 020021, Romania

[2] Colentina Clin Hosp, Dept Neurol, 19-21 Stefan Cel Mare Str, Bucharest 020125, Romania

[3] Carol Davila Univ Med & Pharm, Dept Cellular & Mol Biol & Histol, 8 Eroilor Sanitari Str, Bucharest 050474, Romania

[4] Victor Babes Natl Inst Pathol, Lab Ultrastruct Pathol, 99-101 Splaiul Independentei Str, Bucharest 050096, Romania

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2018年 / 2018卷

关键词：

PARKINSONS-DISEASE; FREE-RADICALS; MOUSE MODEL; DYSFUNCTION; ANTIOXIDANTS; PATHOGENESIS; INFLAMMATION; MECHANISMS; NEUROINFLAMMATION; HYDROGEN;

D O I：

10.1155/2018/2406594

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The gut-brain axis is increasingly recognized as an important pathway of communication and of physiological regulation, and gut microbiota seems to play a significant role in this mutual relationship. Oxidative stress is one of the most important pathogenic mechanisms for both neurodegenerative diseases, such as Alzheimer's or Parkinson's, and acute conditions, such as stroke or traumatic brain injury. A peculiar microbiota type might increase brain inflammation and reactive oxygen species levels and might favor abnormal aggregation of proteins. Reversely, brain lesions of various etiologies result in alteration of gut properties and microbiota. These recent hypotheses could open a door for new therapeutic approaches in various neurological diseases.

引用

页数：12

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