Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk

被引：91

作者：

Ghassibe-Sabbagh, Michella ^{[1
]}

Platt, Daniel E. ^{[2
]}

Youhanna, Sonia ^{[1
]}

Abchee, Antoine B. ^{[3
]}

Stewart, Krista ^{[4
]}

Badro, Danielle A. ^{[1
]}

Haber, Marc ^{[1
]}

Salloum, Angelique K. ^{[1
]}

Douaihy, Bouchra ^{[1
]}

el Bayeh, Hamid ^{[1
]}

Othman, Raed ^{[5
]}

Shasha, Nabil ^{[5
]}

Kibbani, Samer ^{[5
]}

Chammas, Elie ^{[1
]}

Milane, Aline ^{[1
]}

Nemr, Rita ^{[1
]}

Kamatani, Yoichiro ^{[6
]}

Hager, Joerg ^{[7
]}

Cazier, Jean-Baptiste ^{[8
]}

Gauguier, Dominique ^{[8
,9
]}

Zalloua, Pierre A. ^{[1
,10
]}

机构：

[1] Lebanese Amer Univ, Sch Med, Beirut 11022801, Lebanon

[2] IBM TJ Watson Res Ctr, Yorktown Hts, NY 10598 USA

[3] Amer Univ Beirut, Dept Internal Med, Beirut, Lebanon

[4] Univ Wisconsin, Dept Neurol Surg, Madison, WI 53792 USA

[5] Rafic Hariri Univ Hosp, Div Cardiol, Beirut, Lebanon

[6] CEPH, F-75010 Paris, France

[7] CEA, Genom Inst, Ctr Natl Genotypage, F-91057 Evry, France

[8] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

[9] INSERM, UMRS872, Ctr Rech Cordeliers, F-75006 Paris, France

[10] Harvard Univ, Sch Publ Hlth, Boston, MA 02215 USA

来源：

ATHEROSCLEROSIS | 2012年 / 222卷 / 01期

基金：

英国惠康基金;

关键词：

Homocysteine; Coronary artery disease (CAD); Diuretics; Lebanese population; Hypertension; Hyperhomocysteinemia; METHIONINE SYNTHASE REDUCTASE; CARDIOVASCULAR-DISEASE; SERUM HOMOCYSTEINE; VITAMIN THERAPY; POLYMORPHISMS; HYPERTENSION; HYPERHOMOCYSTEINEMIA; POPULATION; SEVERITY; CHINESE;

D O I：

10.1016/j.atherosclerosis.2012.02.035

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Elevated levels of total plasma homocysteine are a risk factor for atherosclerotic disease. Aims: The rationale behind this study is to explore the correlation between degree and site of coronary lesion and hyperhomocysteinemia in Lebanese CAD patients and assess environmental and genetic factors for elevated levels of total plasma homocysteine. Methods: A total of 2644 patients were analyzed for traditional CAD risk factors. Logistic regression was performed to determine the association of hyperhomocysteinemia with degree and site of coronary lesions controlling for risk factors. Environmental and genetic factors for hyperhomocysteinemia were analyzed by logistic regression using a candidate gene approach. Results: Traditional risk factors were correlated with stenosis. Hyperhomocysteinemia associated with increased risk of overall stenosis, and risk of mild and severe occlusion in major arteries. Hyperhomocysteinemia and hypertension were highly correlated suggesting that hyperhomocysteinemia acts as a hypertensive agent leading to CAD. Diuretics and genetic polymorphisms in MTHFR and SLCO1B1 were associated with hyperhomocysteinemia. Conclusions: Hyperhomocysteinemia is a medical indicator of specific vessel stenosis in the Lebanese population. Hypertension is a major link between hyperhomocysteinemia and CAD occurrence. Genetic polymorphisms and diuretics' intake explain partly elevated homocysteine levels. This study has important implications in CAD risk prediction. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：180 / 186

页数：7

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