Protein Databases Related to Liquid-Liquid Phase Separation

被引：32

作者：

Li, Qian ^{[1
]}

Wang, Xi ^{[1
]}

Dou, Zhihui ^{[1
]}

Yang, Weishan ^{[1
]}

Huang, Beifang ^{[1
]}

Lou, Jizhong ^{[1
,2
]}

Zhang, Zhuqing ^{[1
]}

机构：

[1] Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China

[2] Chinese Acad Sci, CAS Ctr Excellence Biomacromol, Inst Biophys, Key Lab RNA Biol, Beijing 100101, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 18期

基金：

中国国家自然科学基金;

关键词：

liquid-liquid phase separation; protein; databases; membraneless organelles; condensates; INTRINSICALLY DISORDERED PROTEINS; TRANSITION; GRANULES; DROPLETS; RESOURCES; COMPLEXES; MUTATION; SYSTEMS; UPDATE;

D O I：

10.3390/ijms21186796

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Liquid-liquid phase separation (LLPS) of biomolecules, which underlies the formation of membraneless organelles (MLOs) or biomolecular condensates, has been investigated intensively in recent years. It contributes to the regulation of various physiological processes and related disease development. A rapidly increasing number of studies have recently focused on the biological functions, driving, and regulating mechanisms of LLPS in cells. Based on the mounting data generated in the investigations, six databases (LLPSDB, PhaSePro, PhaSepDB, DrLLPS, RNAgranuleDB, HUMAN CELL MAP) have been developed, which are designed directly based on LLPS studies or the component identification of MLOs. These resources are invaluable for a deeper understanding of the cellular function of biomolecular phase separation, as well as the development of phase-separating protein prediction and design. In this review, we compare the data contents, annotations, and organization of these databases, highlight their unique features, overlaps, and fundamental differences, and discuss their suitable applications.

引用

页码：1 / 16

页数：15

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