Enantiomeric resolution of axially chiral compounds and interconvertible enantiomers by high-performance liquid chromatography

被引：4

作者：

Fischer, C ^{[1
]}

Modler, A ^{[1
]}

Moinet, C ^{[1
]}

Fiaud, JC ^{[1
]}

机构：

[1] UNIV PARIS 11,INST CHIM MOLEC ORSAY,URA CNRS 1497,LAB SYNTH ASYMETR,F-91405 ORSAY,FRANCE

来源：

JOURNAL OF CHROMATOGRAPHY A | 1996年 / 728卷 / 1-2期

关键词：

enantiomer separation; chiral stationary phases; LC; mobile phase composition; benzylidene cyclohexane derivatives;

D O I：

10.1016/0021-9673(95)01168-4

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Racemic benzylidene cyclohexane derivatives and related compounds were successfully resolved into their enantiomers by HPLC using cellulose and amylose stationary phases. The effect of polar modifiers in the mobile phase on optical resolution on Chiralcel OD-H was studied. Hexane alone as the eluent provided excellent results in many cases; addition of small amounts of alcohols reduced the efficiency drastically. The influence of structural differences of interconvertible enantiomers on the chromatographic resolution was studied.

引用

页码：433 / 439

页数：7

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