Efficient O-demethylation of lignin monoaromatics using the peroxygenase activity of cytochrome P450 enzymes

被引：28

作者：

Harlington, Alix C. ^{[1
]}

Shearwin, Keith E. ^{[1
]}

Bell, Stephen G. ^{[2
]}

Whelan, Fiona ^{[1
]}

机构：

[1] Univ Adelaide, Dept Mol & Biomed Sci, Adelaide, SA 5005, Australia

[2] Univ Adelaide, Dept Chem, Adelaide, SA 5005, Australia

来源：

CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 96期

关键词：

BIOCATALYTIC VALORIZATION; OXIDATION; ACTIVATION; CATABOLISM; PEROXIDE; ACID; P450;

D O I：

10.1039/d2cc04698a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A crucial reaction in harnessing renewable carbon from lignin is O-demethylation. We demonstrate the selective O-demethylation of syringol and guaiacol using different cytochrome P450 enzymes. These can efficiently use hydrogen peroxide which, when compared to nicotinamide cofactor-dependent monooxygenases and synthetic methods, allows for cheap and clean O-demethylation of lignin-derived aromatics.

引用

页码：13321 / 13324

页数：5

共 33 条

[1] A tetrahydrofolate-dependent O-demethylase, LigM, is crucial for catabolism of vanillate and syringate in Sphingomonas paucimobilis SYK-6 [J].

Abe, T ;

Masai, E ;

Miyauchi, K ;

Katayama, Y ;

Fukuda, M .

JOURNAL OF BACTERIOLOGY, 2005, 187 (06) :2030-2037

[2] Microbial assimilation of lignin-derived aromatic compounds and conversion to value-added products [J].

Azubuike, Christopher C. ;

Allemann, Marco N. ;

Michener, Joshua K. .

CURRENT OPINION IN MICROBIOLOGY, 2022, 65 :64-72

[3] A field of dreams: Lignin valorization into chemicals, materials, fuels, and health-care products [J].

Becker, Judith ;

Wittmann, Christoph .

BIOTECHNOLOGY ADVANCES, 2019, 37 (06)

[4]

Bleem A., 2022, CHEM CATAL, V2, P23

[5] Mapping the diversity of microbial lignin catabolism: experiences from the eLignin database [J].

Brink, Daniel P. ;

Ravi, Krithika ;

Liden, Gunnar ;

Gorwa-Grauslund, Marie F. .

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2019, 103 (10) :3979-4002

[6] Rapid, Parallel Identification of Catabolism Pathways of Lignin-Derived Aromatic Compounds in Novosphingobium aromaticivorans [J].

Cecil, Jacob H. ;

Garcia, David C. ;

Giannone, Richard J. ;

Michener, Joshua K. .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2018, 84 (22)

[7] Lignin utilization: A review of lignin depolymerization from various aspects [J].

Chio, Chonlong ;

Sain, Mohini ;

Qin, Wensheng .

RENEWABLE & SUSTAINABLE ENERGY REVIEWS, 2019, 107 :232-249

[8] A self-sufficient peroxide-driven hydroxylation biocatalyst [J].

Cirino, PC ;

Arnold, FH .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (28) :3299-3301

[9] Lignin Monomers from beyond the Canonical Monolignol Biosynthetic Pathway: Another Brick in the Wall [J].

del Rio, Jose C. ;

Rencoret, Jorge ;

Gutierrez, Ana ;

Elder, Thomas ;

Kim, Hoon ;

Ralph, John .

ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2020, 8 (13) :4997-5012

[10] Critical enzyme reactions in aromatic catabolism for microbial lignin conversion [J].

Erickson, Erika ;

Bleem, Alissa ;

Kuatsjah, Eugene ;

Werner, Allison Z. ;

DuBois, Jennifer L. ;

McGeehan, John E. ;

Eltis, Lindsay D. ;

Beckham, Gregg T. .

NATURE CATALYSIS, 2022, 5 (02) :86-98

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