Statistical parametric mapping of interictal 123I-iomazenil SPECT in temporal lobe epilepsy surgery

被引：7

作者：

Fujitani, Shigeru ^{[1
]}

Matsuda, Kazumi ^{[2
]}

Nakamura, Fumihiro ^{[2
]}

Baba, Koichi ^{[2
]}

Usui, Naotaka ^{[2
]}

Tottori, Takayasu ^{[2
]}

Mihara, Tadahiro ^{[2
]}

Terada, Kiyohito ^{[2
]}

Usui, Keiko ^{[2
]}

Inoue, Yushi ^{[2
]}

Kajita, Yasukazu ^{[3
]}

Wakabayashi, Toshihiko ^{[3
]}

机构：

[1] Japanese Red Cross Nagoya First Hosp, Nakamura Ku, Nagoya, Aichi, Japan

[2] Shizuoka Inst Epilepsy & Neurol Disorders, Natl Epilepsy Ctr, Aoi Ku, Shizuoka, Japan

[3] Nagoya Univ, Dept Neurosurg, Grad Sch Med, Showa Ku, Nagoya, Aichi 4648601, Japan

来源：

EPILEPSY RESEARCH | 2013年 / 106卷 / 1-2期

关键词：

Temporal lobe epilepsy; Epileptogenic foci; Single photon emission computed tomography; 123I-iomazenil; Benzodiazepine receptor; Statistical parametric mapping; BENZODIAZEPINE-RECEPTOR-BINDING; I-123; IOMAZENIL; PRESURGICAL IDENTIFICATION; FDG PET; FOCUS; TIME; IMP; ECD;

D O I：

10.1016/j.eplepsyres.2013.03.008

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Brain single photon emission computed tomography (SPECT) for epilepsy is divided into two types (using three radionuclide tracers) perfusion SPECT (123I-IMP or 99 mTc-ECD), identifying epileptogenic foci by detecting abnormality in regional cerebral blood flow, and 123I-iomazenil SPECT, identifying epiteptogenic foci based on distribution of central benzodiazepine receptors. This study aimed to statistically evaluate and compare the SPECT effectiveness for the three tracers. Statistical parametric mapping (SPM) analysis was performed on 30 mesial temporal lobe epilepsy (mTLE) patients. The radionuclide and patient data were categorized as follows: abnormality in the medial temporal lobe on the operated hemisphere (AAA), in the entire temporal lobe on the operated hemisphere (AA), in the dominantly affected temporal lobe on the operated hemisphere (A), in bilateral temporal lobes (B), with no abnormalities in bilateral temporal lobes (C), and with abnormality in the temporal lobe on the nonoperated hemisphere (D). For analyses of (AAA), (AA), and (A), examining the hemisphere containing epileptogenic foci, IMP-SPECT was significantly superior to ECD-SPECT (P<0.05). For (AAA), indicating localization, IMZ-SPECT was significantly superior to the other two (P<0.05). IMP-SPECT was superior for lateralizing and IMZ-SPECT was useful for localizing epileptogenic foci in mTLE patients though the applicability of the results in extratemporal lobe epilepsy is unknown. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：173 / 180

页数：8

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