Regulation of activity of transcription factor NF-κB by synthetic oligonucleotides

被引：7
作者：
Metelev, V. G. [1 ]
Kubareva, E. A. [1 ]
Oretskaya, T. S. [1 ]
机构：
[1] Moscow MV Lomonosov State Univ, Belozersky Inst Physicochem Biol, Fac Chem, Moscow 119991, Russia
来源：
BIOCHEMISTRY-MOSCOW | 2013年 / 78卷 / 08期
关键词：
transcription factor NF-kappa B; modified oligonucleotides; antisense oligonucleotides; oligonucleotides decoys; aptamers; IN-VIVO TRANSFECTION; MICROENCAPSULATED ANTISENSE OLIGOMERS; CHIMERIC DECOY OLIGODEOXYNUCLEOTIDE; CARDIAC ALLOGRAFT SURVIVAL; CIS-ELEMENT DECOY; BINDING-SITE; GENE-THERAPY; P65; SUBUNIT; CELL-DEATH; INHIBITION;
D O I：
10.1134/S0006297913080026
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Eukaryotic dimeric nuclear factor-kappa B (NF-kappa B) is one of the main transcription factors that activate expression of genes, products of which play the key role in development of cardiovascular pathologies, carcinogenesis, and inflammatory and viral diseases. In this review, the main attention is given to modulation of the transcription factor NF-kappa B activity by antisense oligonucleotides and oligonucleotide decoys. Also, current concepts about interactions between NF-kappa B dimers and DNA and general problems that arise in experimental use of synthetic oligonucleotides in vivo are discussed.
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收藏
页码：867 / 878
页数：12
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