Co-administration of flagellin augments immune responses to inactivated foot-and-mouth disease virus (FMDV) antigen

被引：24
|
作者：
Hajam, Irshad A. [1 ]
Dar, Pervaiz A. [1 ,2 ]
ChandraSekar, Shanmugam [1 ]
Nanda, Raj Kishore [1 ]
Kishore, Subodh [1 ]
Bhanuprakash, Veerakyathappa [1 ]
Ganesh, Kondabattula [1 ]
机构：
[1] Indian Vet Res Inst, FMD Res Ctr, Bangalore 560024, Karnataka, India
[2] SKUAST Kashmir, Div Vet Microbiol & Immunol, Fac Vet Sci & Anim Husb, Srinagar 190006, Jammu & Kashmir, India
来源：
RESEARCH IN VETERINARY SCIENCE | 2013年 / 95卷 / 03期
关键词：
Flagellin; Foot-and-mouth disease virus; Immune response; Molecular adjuvant; Guinea pig; BACTERIAL FLAGELLIN; EFFECTIVE ADJUVANT; DNA VACCINE; CARRIER; INNATE; CELLS; TYPHIMURIUM; MECHANISMS; EFFICACY; MUCOSAL;
D O I：
10.1016/j.rvsc.2013.07.021
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Foot-and-mouth disease virus (FMDV) is one of the most contagious animal virus known that affects livestock health and production. This study aimed to investigate the effect of flagellin, a toll-like receptor 5 agonist, on the immune responses to inactivated FMDV antigen in guinea pig model. Our results showed that the co-administration of flagellin with FMDV antigen through intradermal route induces earlier and higher anti-FMDV neutralizing antibody responses as compared to FMDV antigen alone. Both IgG(1) and IgG(2) antibody-isotype responses were enhanced, but the IgG(1)/IgG(2) ratios were relatively low, indicative of T(H)1 type of immune activation. On live viral challenge, flagellin + FMDV immunized guinea pigs showed 70% (7 out of 10) protection rate as compared to 40% (4 out of 10) in FMDV alone immunized guinea pigs. The results demonstrate that the co-administration of flagellin augments immune responses (Preferably T(H)1 type) and protective efficacy against FMDV in guinea pigs. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：936 / 941
页数：6
相关论文
共 50 条
  • [31] Foot-and-mouth disease virus (FMDV) leader proteinase negatively regulates the porcine interferon-λ1 pathway
    Wang, Dang
    Fang, Liurong
    Liu, Lizhi
    Zhong, Huijuan
    Chen, Quangang
    Luo, Rui
    Liu, Xiangtao
    Zhang, Zhongming
    Chen, Huanchun
    Xiao, Shaobo
    MOLECULAR IMMUNOLOGY, 2011, 49 (1-2) : 407 - 412
  • [32] Immune responses to foot-and-mouth disease DNA Vaccines can be enhanced by coinjection with the Isatis indigotica extract
    Chen, L
    Lin, T
    Zhang, HX
    Su, YB
    INTERVIROLOGY, 2005, 48 (04) : 207 - 212
  • [33] Chuanminshen violaceum polysaccharides improve the immune responses of foot-and-mouth disease vaccine in mice
    Feng, Haibo
    Fan, Jing
    Qiu, Hong
    Wang, Zhenhua
    Yan, Zhiqiang
    Yuan, Lihua
    Guan, Lu
    Du, Xiaogang
    Song, Zhenhui
    Han, Xingfa
    Liu, Juan
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2015, 78 : 405 - 416
  • [34] Interleukin-2 potentiates foot-and-mouth disease vaccinal immune responses in mice
    Yadav, S
    Sharma, R
    Chhabra, R
    VACCINE, 2005, 23 (23) : 3005 - 3009
  • [35] A ferritin-based nanoparticle displaying a neutralizing epitope for foot-and-mouth disease virus (FMDV) confers partial protection in guinea pigs
    Lu, Bingzhou
    Ru, Yi
    Hao, Rongzeng
    Yang, Yang
    Liu, Huanan
    Li, Yajun
    Zhang, Yue
    Mao, Yuhan
    Yang, Rui
    Pan, Yangyang
    Yu, Sijiu
    Zheng, Haixue
    Cui, Yan
    BMC VETERINARY RESEARCH, 2024, 20 (01)
  • [36] Rapid protection of cattle from direct challenge with foot-and-mouth disease virus (FMDV) by a single inoculation with an adenovirus-vectored FMDV subunit vaccine
    Pacheco, JM
    Brum, MCS
    Moraes, MP
    Golde, WT
    Grubman, MJ
    VIROLOGY, 2005, 337 (02) : 205 - 209
  • [37] Immunogenicity and protective efficacy of recombinant proteins consisting of multiple epitopes of foot-and-mouth disease virus fused with flagellin
    Cui, Baofeng
    Liu, Xinsheng
    Zhou, Peng
    Fang, Yuzhen
    Zhao, Donghong
    Zhang, Yongguang
    Wang, Yonglu
    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2019, 103 (08) : 3367 - 3379
  • [38] Quantitative trait loci for variation in immune response to a Foot-and-Mouth Disease virus peptide
    Leach, Richard J.
    Craigmile, Susan C.
    Knott, Sara A.
    Williams, John L.
    Glass, Elizabeth J.
    BMC GENETICS, 2010, 11
  • [39] Local and systemic immune responses induced by intranasal immunization with biomineralized foot-and-mouth disease virus-like particles
    Li, Shuo
    Zhao, Ruichong
    Song, Hetao
    Pan, Songjia
    Zhang, Yun
    Dong, Hu
    Bai, Manyuan
    Sun, Shiqi
    Guo, Huichen
    Yin, Shuanghui
    FRONTIERS IN MICROBIOLOGY, 2023, 14
  • [40] Immunogenicity and protective efficacy of recombinant proteins consisting of multiple epitopes of foot-and-mouth disease virus fused with flagellin
    Baofeng Cui
    Xinsheng Liu
    Peng Zhou
    Yuzhen Fang
    Donghong Zhao
    Yongguang Zhang
    Yonglu Wang
    Applied Microbiology and Biotechnology, 2019, 103 : 3367 - 3379
12345