Co-administration of flagellin augments immune responses to inactivated foot-and-mouth disease virus (FMDV) antigen

被引：24
|
作者：
Hajam, Irshad A. [1 ]
Dar, Pervaiz A. [1 ,2 ]
ChandraSekar, Shanmugam [1 ]
Nanda, Raj Kishore [1 ]
Kishore, Subodh [1 ]
Bhanuprakash, Veerakyathappa [1 ]
Ganesh, Kondabattula [1 ]
机构：
[1] Indian Vet Res Inst, FMD Res Ctr, Bangalore 560024, Karnataka, India
[2] SKUAST Kashmir, Div Vet Microbiol & Immunol, Fac Vet Sci & Anim Husb, Srinagar 190006, Jammu & Kashmir, India
来源：
RESEARCH IN VETERINARY SCIENCE | 2013年 / 95卷 / 03期
关键词：
Flagellin; Foot-and-mouth disease virus; Immune response; Molecular adjuvant; Guinea pig; BACTERIAL FLAGELLIN; EFFECTIVE ADJUVANT; DNA VACCINE; CARRIER; INNATE; CELLS; TYPHIMURIUM; MECHANISMS; EFFICACY; MUCOSAL;
D O I：
10.1016/j.rvsc.2013.07.021
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Foot-and-mouth disease virus (FMDV) is one of the most contagious animal virus known that affects livestock health and production. This study aimed to investigate the effect of flagellin, a toll-like receptor 5 agonist, on the immune responses to inactivated FMDV antigen in guinea pig model. Our results showed that the co-administration of flagellin with FMDV antigen through intradermal route induces earlier and higher anti-FMDV neutralizing antibody responses as compared to FMDV antigen alone. Both IgG(1) and IgG(2) antibody-isotype responses were enhanced, but the IgG(1)/IgG(2) ratios were relatively low, indicative of T(H)1 type of immune activation. On live viral challenge, flagellin + FMDV immunized guinea pigs showed 70% (7 out of 10) protection rate as compared to 40% (4 out of 10) in FMDV alone immunized guinea pigs. The results demonstrate that the co-administration of flagellin augments immune responses (Preferably T(H)1 type) and protective efficacy against FMDV in guinea pigs. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：936 / 941
页数：6
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