miR-134 inhibits osteosarcoma cell invasion and metastasis through targeting MMP1 and MMP3 in vitro and in vivo

被引：53

作者：

Chen, Cheng-long ^{[1
]}

Zhang, Long ^{[2
]}

Jiao, Yu-rui ^{[1
]}

Zhou, Yi ^{[3
]}

Ge, Qiao-feng ^{[1
]}

Li, Peng-cui ^{[4
]}

Sun, Xiao-juan ^{[4
]}

Lv, Zhi ^{[2
]}

机构：

[1] Shanxi Med Univ, Clin Med Coll 2, Taiyuan, Shanxi, Peoples R China

[2] Shanxi Med Univ, Hosp 2, Dept Orthopaed, 382 Wuyi Rd, Taiyuan 030001, Shanxi, Peoples R China

[3] Southern Med Univ, Clin Med Sch 1, Guangzhou, Guangdong, Peoples R China

[4] Shanxi Med Univ, Hosp 1, Shanxi Key Lab Bone & Soft Tissue Injury Repair, 382 Wuyi Rd, Taiyuan 030001, Shanxi, Peoples R China

来源：

FEBS LETTERS | 2019年 / 593卷 / 10期

关键词：

invasion; matrix metalloproteinases; metastasis; miR-134; osteosarcoma; EXTRACELLULAR-MATRIX; DECREASED EXPRESSION; TISSUE INHIBITOR; TUMOR; GENE; METALLOPROTEINASES; MIGRATION; ASSOCIATION; BIOGENESIS; PROGNOSIS;

D O I：

10.1002/1873-3468.13387

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

miR-134 has been shown to be associated with angiogenesis and the progression of osteosarcoma. This study further assessed the effects of miR-134 expression on osteosarcoma cell migration, invasion, and metastasis in vitro and in a nude mouse xenograft model, exploring the underlying molecular events. Luciferase reporter assays revealed that miR-134 directly targets the 3 '-UTRs of MMP1 and MMP3 to reduce their expression in osteosarcoma cells. In conclusion, overexpression of miR-134 suppresses osteosarcoma cell invasion and metastasis through the inhibition of MMP1 and MMP3 expression. We propose miR-134 as an attractive novel therapeutic target for the treatment of osteosarcoma.

引用

页码：1089 / 1101

页数：13

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