The Effects of Ascorbic Acid and U-74389G on Renal Ischemia-Reperfusion Injury in a Rat Model

被引：3

作者：

Zografos, Constantinos G. ^{[1
,2
]}

Chrysikos, Dimosthenis ^{[1
,2
]}

Pittaras, Theodoros ^{[1
,3
]}

Karampelias, Vasileios ^{[4
]}

Chairakakis, Aikaterini ^{[1
]}

Galanos, Antonis ^{[1
]}

Sfiniadakis, Ioannis ^{[5
]}

Felekouras, Evangelos ^{[6
]}

Zografos, George C. ^{[2
]}

Sideris, Michail ^{[7
]}

Papadopoulou, Konstantina ^{[1
]}

Papalois, Apostolos E. ^{[1
,8
]}

机构：

[1] Expt Educ & Res Ctr ELPEN, Athens, Greece

[2] Hippokrateion Hosp, Dept Propaedeut Surg 1, Athens, Greece

[3] Natl & Kapodistrian Univ Athens, Aretaie Hosp, Hematol Lab Blood Bank, Sch Med, Athens, Greece

[4] Univ Patras, Sch Med, Patras, Greece

[5] Athens Naval Hosp, Pathol Lab, Athens, Greece

[6] Natl & Kapodistrian Univ Athens, Laikon Gen Hosp, Dept Surg 1, Athens, Greece

[7] Queen Mary Univ London, Barts & London Sch Med & Dent, London, England

[8] European Univ Cyprus, Sch Med, Nicosia, Cyprus

来源：

IN VIVO | 2020年 / 34卷 / 05期

关键词：

Antioxidants; ascorbic acid; kidney; reperfusion injury; STEM-CELLS CONTRIBUTE; LAZAROID U-74389G; EPITHELIAL-CELLS; LIVER; KIDNEY; REGENERATION; PANCREATITIS; PROTECTION; APOPTOSIS; RECOVERY;

D O I：

10.21873/invivo.12063

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background/Aim: U-74389G and ascorbic acid protect the cells from oxidation. This study aimed to depict their role in ischemia-reperfusion injury in a renal rat model. Materials and Methods: Sixty Wistars rats were randomized into six groups of 10 animals each. Group A Ischemia 30 min, reperfusion 60 min; Group B Ischemia 30 min, reperfusion 120 min; Group C Ischemia 30 min, ascorbic acid administration, reperfusion 60 min; Group D Ischemia 30 min, ascorbic acid administration, reperfusion 120 min; Group E Ischemia 30 min, U-74389G administration, reperfusion 60 min; Group F Ischemia 30 min, U-74389G administration, reperfusion 120 min. We then collected tissue and blood samples. Results: Histology and the significantly decreased malondialdehyde and tumor necrosis factor-alpha levels indicated that ascorbic acid was superior to U-74389G, at pre-defined time intervals. Conclusion: Ascorbic acid and U-743896 ameliorated renal damage induced by ischemia-reperfusion injury, suggesting a therapeutic effect.

引用

页码：2475 / 2484

页数：10

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