High Viral Load and Respiratory Failure in Adults Hospitalized for Respiratory Syncytial Virus Infections

被引：40

作者：

Lee, Nelson ^{[1
,2
]}

Chan, Martin C. W. ^{[3
]}

Lui, Grace C. Y. ^{[1
]}

Li, Ran ^{[4
]}

Wong, Rity Y. K. ^{[1
]}

Yung, Irene M. H. ^{[1
]}

Cheung, Catherine S. K. ^{[1
]}

Chan, Eugenia C. Y. ^{[3
]}

Hui, David S. C. ^{[1
,2
]}

Chan, Paul K. S. ^{[2
,3
]}

机构：

[1] Chinese Univ Hong Kong, Fac Med, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Fac Med, Stanley Ho Ctr Emerging Infect Dis, Shatin, Hong Kong, Peoples R China

[3] Chinese Univ Hong Kong, Fac Med, Dept Microbiol, Shatin, Hong Kong, Peoples R China

[4] Capital Med Univ, Beijing Chao Yang Hosp, Beijing Inst Resp Med, Dept Infect Dis & Clin Microbiol, Beijing, Peoples R China

来源：

JOURNAL OF INFECTIOUS DISEASES | 2015年 / 212卷 / 08期

关键词：

respiratory failure; RSV; viral load; DISEASE; INFLUENZA; RSV; PCR;

D O I：

10.1093/infdis/jiv248

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A prospective study among adults hospitalized for polymerase chain reaction-confirmed respiratory syncytial virus infections (n = 123) showed frequent occurrence of lower respiratory-tract complications causing respiratory insufficiency (52.8%), requirement for assisted ventilation (16.3%), and intensive care unit admission/death (12.2%). High viral RNA concentration was detected at time of hospitalization, including in patients who presented later than 2 days of illness (day 1-2, 7.29 +/- 1.47; day 3-4, 7.28 +/- 1.41; day 5-8, 6.66 +/- 1.87 log10 copies/mL). RNA concentration was independently associated with risk of complications and respiratory insufficiency (adjusted odds ratio 1.40 per log(10) copies/mL increase, 95% confidence interval, 1.03-1.90; P = .034). Our data indicate the need and provide a basis for clinical research on antiviral therapy in this population.

引用

页码：1237 / 1240

页数：4

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