The Merkel Cell Polyomavirus and Its Involvement in Merkel Cell Carcinoma

被引：31
作者：
Amber, Kyle [1 ]
McLeod, Michael P. [1 ]
Nouri, Keyvan [1 ]
机构：
[1] Univ Miami, Miller Sch Med, Dept Dermatol & Cutaneous Surg, Miami, FL 33136 USA
来源：
DERMATOLOGIC SURGERY | 2013年 / 39卷 / 02期
关键词：
LARGE T-ANTIGEN; INFECTION; EXPRESSION; SIMIAN-VIRUS-40; ASSOCIATION; INTEGRATION; SURVIVAL; DOMAIN; SV40; MCV;
D O I：
10.1111/dsu.12079
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Background The discovery of the Merkel cell polyomavirus (MCV) in a large number of Merkel cell carcinomas (MCCs) has led to many investigations into its potential role as an oncovirus. Many studies have recently explored the differences between MCCs infected and not infected with MCV. Objective To review the role of MCV in MCC and its potential to influence diagnosis, prognosis, and treatment. Methods and Materials An extensive literature search was performed on MCV and its relationship with other polyomaviruses and MCC. The immune system's role in MCC was also investigated. Results We included 60 articles regarding MCC and MCV and seven pertinent to general processes involved with MCC and MCV. Conclusion Merkel cell polyomavirus appears to affect many aspects of MCC. An understanding of this virus may aid in future therapy options and current pathology protocols in diagnosing MCC. The host's immune function appears to affect MCV's ability to cause cellular transformation leading to MCC.
引用
收藏
页码：232 / 238
页数：7
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