Demonstration of a Mid-Infrared Cavity Enhanced Absorption Spectrometer for Breath Acetone Detection

被引：67

作者：

Ciaffoni, Luca ^{[1
]}

Hancock, Gus ^{[1
]}

Harrison, Jeremy J. ^{[2
]}

van Helden, Jean-Pierre H. ^{[1
]}

Langley, Cathryn E. ^{[1
]}

Peverall, Robert ^{[1
]}

Ritchie, Grant A. D. ^{[1
]}

Wood, Simon ^{[1
]}

机构：

[1] Univ Oxford, Dept Chem, Phys & Theoret Chem Lab, Oxford OX1 3QZ, England

[2] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

来源：

ANALYTICAL CHEMISTRY | 2013年 / 85卷 / 02期

关键词：

EXHALED BREATH; SPECTROSCOPY;

D O I：

10.1021/ac3031465

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A high-resolution absorption spectrum of gaseous acetone near 8.2 mu m has been taken using both Fourier transform and quantum cascade laser (QCL)-based infrared spectrometers. Absolute absorption cross sections within the 1215-1222 cm(-1) range have been determined, and the spectral window around 1216.5 cm(-1) (sigma = 3.4 X 10(-19) cm(2) molecule(-1)) has been chosen for monitoring trace acetone in exhaled breath. Acetone at sub parts-per-million (ppm) levels has been measured in a breath sample with a precision of 0.17 ppm (1 sigma) by utilizing a cavity enhanced absorption spectrometer constructed from the QCL source and a linear, low-volume, optical cavity. The use of a water vapor trap ensured the accuracy of the results, which have been corroborated by mass spectrometric measurements.

引用

页码：846 / 850

页数：5

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