Casting a wider net for diabetes susceptibility genes

被引:58
作者
McCarthy, Mark I. [1 ,2 ]
机构
[1] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England
[2] Oxford Natl Inst Hlth Res, Biomed Res Ctr, Oxford, England
关键词
D O I
10.1038/ng0908-1039
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Recent successes in identifying loci involved in predisposition to type 2 diabetes have been driven by genome-wide association studies in populations of European descent. a new discovery, using samples of east Asian origin, of diabetes susceptibility variants mapping to the KCNQ1 gene highlights the importance of extending these studies to a wider range of populations.
引用
收藏
页码:1039 / 1040
页数:2
相关论文
共 15 条
  • [1] Genome-wide association studies provide new insights into type 2 diabetes aetiology
    Frayling, Timothy M.
    [J]. NATURE REVIEWS GENETICS, 2007, 8 (09) : 657 - 662
  • [2] Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
    Grant, SFA
    Thorleifsson, G
    Reynisdottir, I
    Benediktsson, R
    Manolescu, A
    Sainz, J
    Helgason, A
    Stefansson, H
    Emilsson, V
    Helgadottir, A
    Styrkarsdottir, U
    Magnusson, KP
    Walters, GB
    Palsdottir, E
    Jonsdottir, T
    Gudmundsdottir, T
    Gylfason, A
    Saemundsdottir, J
    Wilensky, RL
    Reilly, MP
    Rader, DJ
    Bagger, Y
    Christiansen, C
    Gudnason, V
    Sigurdsson, G
    Thorsteinsdottir, U
    Gulcher, JR
    Kong, A
    Stefansson, K
    [J]. NATURE GENETICS, 2006, 38 (03) : 320 - 323
  • [3] Human KVLQT1 gene shows tissue-specific imprinting and encompasses Beckwith-Wiedemann syndrome chromosomal rearrangements
    Lee, MP
    Hu, RJ
    Johnson, LA
    Feinberg, AP
    [J]. NATURE GENETICS, 1997, 15 (02) : 181 - 185
  • [4] Genome-wide association studies for complex traits: consensus, uncertainty and challenges
    McCarthy, Mark I.
    Abecasis, Goncalo R.
    Cardon, Lon R.
    Goldstein, David B.
    Little, Julian
    Ioannidis, John P. A.
    Hirschhorn, Joel N.
    [J]. NATURE REVIEWS GENETICS, 2008, 9 (05) : 356 - 369
  • [5] Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population
    Mori, Shintaro
    Tanaka, Yasushi
    Takahashi, Atsushi
    Hirose, Hiroshi
    Kashiwagi, Atsunori
    Kaku, Kohei
    Kawamori, Ryuzo
    Nakamura, Yusuke
    Maeda, Shiro
    [J]. DIABETES, 2008, 57 (03) : 791 - 795
  • [6] NEEL JV, 1962, AM J HUM GENET, V14, P353
  • [7] A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome
    Neyroud, N
    Tesson, F
    Denjoy, I
    Leibovici, M
    Donger, C
    Barhanin, J
    Faure, S
    Gary, F
    Coumel, P
    Petit, C
    Schwartz, K
    Guicheney, P
    [J]. NATURE GENETICS, 1997, 15 (02) : 186 - 189
  • [8] Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians
    Ng, Maggie C. Y.
    Park, Kyong Soo
    Oh, Bermseok
    Tam, Claudia H. T.
    Cho, Young Min
    Shin, Hyoung Doo
    Lam, Vincent K. L.
    Ma, Ronald C. W.
    So, Wing Yee
    Cho, Yoon Shin
    Kim, Hyung-Lae
    Lee, Hong Kyu
    Chan, Juliana C. N.
    Cho, Nam H.
    [J]. DIABETES, 2008, 57 (08) : 2226 - 2233
  • [9] Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic β-cell function
    Pascoe, Laura
    Tura, Andrea
    Patel, Sheila K.
    Ibrahim, M. Ibrahim
    Ferrannini, Ele
    Zeggini, Eleftheria
    Weedon, Michael N.
    Mari, Andrea
    Hattersley, Andrew T.
    McCarthy, Mark I.
    Frayling, Timothy M.
    Walker, Mark
    [J]. DIABETES, 2007, 56 (12) : 3101 - 3104
  • [10] Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs:: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk
    Sanghera, Dharambir K.
    Ortega, Lyda
    Han, Shizhong
    Singh, Jairup
    Ralhan, Sarju K.
    Wander, Gurpreet S.
    Mehra, Narinder K.
    Mulvihill, John J.
    Ferrell, Robert E.
    Nath, Swapan K.
    Kamboh, Mohammed I.
    [J]. BMC MEDICAL GENETICS, 2008, 9