Safety and efficacy of low-dose clopidogrel in Japanese patients undergoing coronary stenting - Preliminary 30-day clinical outcome

被引：9

作者：

Asano, Tatsuhiko ^{[1
]}

Kobayashi, Yoshio ^{[1
]}

Fukushima, Kenichi ^{[1
]}

Iwata, Yo ^{[1
]}

Kitahara, Hideki ^{[1
]}

Ishio, Naoki ^{[1
]}

Kuroda, Nakabumi ^{[1
]}

Komuro, Issei ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Med, Dept Cardiovasc Sci & Med, Chiba, Japan

来源：

CIRCULATION JOURNAL | 2008年 / 72卷 / 10期

关键词：

antiplatelet therapy; stents; stent thrombosis;

D O I：

10.1253/circj.CJ-08-0401

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background A lower maintenance dose of clopidogrel may be appropriate in Japanese patients because the maintenance dose of ticlopidine is lower in Japan than that used in the United States. Methods and Results A total of 126 patients with 153 lesions who consented to take 50-mg clopidogrel to prevent stern thrombosis were enrolled. There was 1 case of early stent thrombosis (0.65%). Side-effects of clopidogrel occured in 5 patients (4.0%). Conclusion This preliminary Study shows that 50mg clopidogrel may be acceptable in Japanese patients.

引用

页码：1707 / 1708

页数：2

共 5 条

[1]

FUKUSHIMA K, 2008, JPN J INTERV CARDI S, V23, P340

[2] Incidence of side-effects of ticlopidine after sirolimus-eluting stent implantation - Retrospective analysis from three hospitals [J].

Fukushima, Kenichi ;

Kobayashi, Yoshio ;

Okuno, Tomonobu ;

Nakamura, Yoshitake ;

Sakakibara, Masayoshi ;

Nakayama, Takashi ;

Kuroda, Nakabumi ;

Miyazaki, Akira ;

Shimizu, Youichi ;

Komuro, Issei .

CIRCULATION JOURNAL, 2007, 71 (04) :617-619

[3] Ticlopidine-induced hepatotoxicity is associated with specific human leukocyte antigen genomic subtypes in Japanese patients: a preliminary case-control study [J].

Hirata, K. ;

Takagi, H. ;

Yamamoto, M. ;

Matsumoto, T. ;

Nishiya, T. ;

Mori, K. ;

Shimizu, S. ;

Masumoto, H. ;

Okutani, Y. .

PHARMACOGENOMICS JOURNAL, 2008, 8 (01) :29-33

[4] Documented subacute stent thrombosis within thirty days after stenting with sirolimus-eluting stent (Cypher®) for acute myocardial infarction -: A Japanese single center retrospective non-randomized study [J].

Ishikawa, Tetsuya ;

Mutoh, Makoto ;

Fuda, Yuji ;

Sakamoto, Hiroshi ;

Okada, Hisayuki ;

Higashitani, Michiaki ;

Nakano, Yousuke ;

Yamaguchi, Junichi ;

Enta, Kenji ;

Satoh, Takahiro ;

Imai, Kamon ;

Horie, Toshinobu ;

Mochizuki, Seibu .

CIRCULATION JOURNAL, 2006, 70 (08) :1091-1092

[5] Late stent thrombosis in patients receiving ticlopidine and aspirin after sirolimus-eluting stent implantation [J].

Kitahara, Hideki ;

Kobayashi, Yoshio ;

Fujimoto, Yoshihide ;

Nakamura, Yoshitake ;

Nakayama, Takashi ;

Kuroda, Nakabumi ;

Himi, Toshiharu ;

Miyazaki, Akira ;

Komuro, Issei .

CIRCULATION JOURNAL, 2008, 72 (01) :168-169

← 1 →