Similar -Synuclein staining in the colon mucosa in patients with Parkinson's disease and controls

被引：40

作者：

Antunes, Laurent ^{[1
]}

Frasquilho, Sonia ^{[1
]}

Ostaszewski, Marek ^{[1
,2
]}

Weber, Jos. ^{[3
]}

Longhino, Laura ^{[4
]}

Antony, Paul ^{[2
]}

Baumuratov, Aidos ^{[2
]}

Buttini, Manuel ^{[2
]}

Shannon, Kathleen M. ^{[5
]}

Balling, Rudi ^{[2
]}

Diederich, Nico J. ^{[2
,4
]}

机构：

[1] Integrated Biobank Luxembourg, Dept Pathol, Luxembourg, Luxembourg

[2] Ctr Hosp Luxembourg, Dept Gastroenterol, Luxembourg, Luxembourg

[3] Univ Luxembourg, Luxembourg Ctr Syst Biomed, Esch Sur Alzette, Luxembourg

[4] Ctr Hosp Luxembourg, Dept Neurol, 4 Rue Barble, L-1210 Luxembourg, Luxembourg

[5] Rush Univ, Dept Neurol Sci, Chicago, IL 60612 USA

来源：

MOVEMENT DISORDERS | 2016年 / 31卷 / 10期

关键词：

Parkinson's disease; alpha-synuclein; mucosa; colon; biomarker; ENTERIC NERVOUS-SYSTEM; ALPHA-SYNUCLEIN; LACKS SPECIFICITY; BIOMARKER; PATHOLOGY;

D O I：

10.1002/mds.26702

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

BackgroundThe gut is proposed as a starting point of idiopathic IPD, but the presence of -synuclein in the IPD colon mucosa is debated. ObjectivesThe objective of this study was to evaluate if -synuclein in the colon mucosa can serve as a biomarker of IPD. MethodsImmunohistochemistry was used to locate and quantify in a blinded approach -synuclein in the mucosa from biopsies of the right and left colon in 19 IPD patients and 8 controls. ResultsTotal -synuclein was present in all but 1 IPD patients and in all controls; phosphorylated -synuclein was present in all subjects. There was no intensity difference depending on disease status. Staining of total -synuclein was stronger in the right colon (p = .04). ConclusionsConventional immunohistochemistry -synuclein staining in colon mucosal biopsies cannot serve as a biomarker of idiopathic PD. These findings do not contradict the assumption of disease starting in the colon, and a colon segment-specific risk for disease initiation can still be hypothesized. (c) 2016 International Parkinson and Movement Disorder Society

引用

页码：1567 / 1570

页数：4

共 20 条

[1] Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders [J].

Beach, Thomas G. ;

Adler, Charles H. ;

Sue, Lucia I. ;

Vedders, Linda ;

Lue, LihFen ;

White, Charles L., III ;

Akiyama, Haru ;

Caviness, John N. ;

Shill, Holly A. ;

Sabbagh, Marwan N. ;

Walker, Douglas G. .

ACTA NEUROPATHOLOGICA, 2010, 119 (06) :689-702

[2] Expression pattern and localization of alpha-synuclein in the human enteric nervous system [J].

Boettner, Martina ;

Zorenkov, Dimitri ;

Hellwig, Ines ;

Barrenschee, Martina ;

Harde, Jonas ;

Fricke, Tobias ;

Deuschl, Guenther ;

Egberts, Jan-Hendrik ;

Becker, Thomas ;

Fritscher-Ravens, Annette ;

Arlt, Alexander ;

Wedel, Thilo .

NEUROBIOLOGY OF DISEASE, 2012, 48 (03) :474-480

[3] Idiopathic Parkinson's disease:: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen [J].

Braak, H ;

Rüb, U ;

Gai, WP ;

Del Tredici, K .

JOURNAL OF NEURAL TRANSMISSION, 2003, 110 (05) :517-536

[4] Alpha-synuclein in gastric and colonic mucosa in Parkinson's disease: Limited role as a biomarker [J].

Chung, Sun Ju ;

Kim, Juyeon ;

Lee, Hyo Jeong ;

Ryu, Ho-Sung ;

Kim, Kiju ;

Lee, Jeong Hoon ;

Jung, Kee Wook ;

Kim, Mi Jung ;

Kim, Mi-Jung ;

Kim, Young Jin ;

Yun, Sung-Cheol ;

Lee, Joo-Yong ;

Hong, Seung-Mo ;

Myung, Seung-Jae .

MOVEMENT DISORDERS, 2016, 31 (02) :241-249

[5] Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations [J].

Dehay, Benjamin ;

Bourdenx, Mathieu ;

Gorry, Philippe ;

Przedborski, Serge ;

Vila, Miquel ;

Hunot, Stephane ;

Singleton, Andrew ;

Olanow, C. Warren ;

Merchant, Kalpana M. ;

Bezard, Erwan ;

Petsko, Gregory A. ;

Meissner, Wassilios G. .

LANCET NEUROLOGY, 2015, 14 (08) :855-866

[6] Discriminative Power of Different Nonmotor Signs in Early Parkinson's Disease. A Case-Control Study [J].

Diederich, Nico J. ;

Pieri, Vannina ;

Hipp, Geraldine ;

Rufra, Olivier ;

Blyth, Sara ;

Vaillant, Michel .

MOVEMENT DISORDERS, 2010, 25 (07) :882-887

[7] Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease [J].

Forsyth, Christopher B. ;

Shannon, Kathleen M. ;

Kordower, Jeffrey H. ;

Voigt, Robin M. ;

Shaikh, Maliha ;

Jaglin, Jean A. ;

Estes, Jacob D. ;

Dodiya, Hemraj B. ;

Keshavarzian, Ali .

PLOS ONE, 2011, 6 (12)

[8] Multiple Organ Involvement by Alpha-Synuclein Pathology in Lewy Body Disorders [J].

Gelpi, Ellen ;

Navarro-Otano, Judith ;

Tolosa, Eduardo ;

Gaig, Carles ;

Compta, Yaroslau ;

Jesus Rey, Maria ;

Jose Marti, Maria ;

Hernandez, Isabel ;

Valldeoriola, Francesc ;

Rene, Ramon ;

Ribalta, Teresa .

MOVEMENT DISORDERS, 2014, 29 (08) :1010-1018

[9] Alpha-Synuclein in the Appendiceal Mucosa of Neurologically Intact Subjects [J].

Gray, Madison T. ;

Munoz, David G. ;

Gray, Douglas A. ;

Schlossmacher, Michael G. ;

Woulfe, John M. .

MOVEMENT DISORDERS, 2014, 29 (08) :991-998

[10] Accumulation of α-synuclein in the bowel of patients in the pre-clinical phase of Parkinson's disease [J].

Hilton, David ;

Stephens, Madeleine ;

Kirk, Leanne ;

Edwards, Philip ;

Potter, Ross ;

Zajicek, John ;

Broughton, Ellie ;

Hagan, Hannah ;

Carroll, Camille .

ACTA NEUROPATHOLOGICA, 2014, 127 (02) :235-241

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