High Prevalence of Cerebral Microbleeds at 7Tesla MRI in Patients with Early Alzheimer's Disease

被引：85

作者：

Brundel, Manon ^{[1
]}

Heringa, Sophie M. ^{[1
]}

de Bresser, Jeroen ^{[1
,2
]}

Koek, Huiberdina L. ^{[3
]}

Zwanenburg, Jaco J. M. ^{[2
,4
]}

Kappelle, L. Jaap ^{[1
]}

Luijten, Peter R. ^{[4
]}

Biessels, Geert Jan ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Neurol, NL-3508 GA Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, Image Sci Inst, NL-3508 GA Utrecht, Netherlands

[3] Univ Med Ctr Utrecht, Dept Geriatr, NL-3508 GA Utrecht, Netherlands

[4] Univ Med Ctr Utrecht, Dept Radiol, NL-3508 GA Utrecht, Netherlands

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2012年 / 31卷 / 02期

关键词：

Alzheimer's disease; magnetic resonance imaging; mild cognitive impairment; MILD COGNITIVE IMPAIRMENT; BRAIN; PATHOLOGY; SCALE;

D O I：

10.3233/JAD-2012-120364

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The prevalence of microbleeds on magnetic resonance imaging (MRI) in patients with Alzheimer's disease (AD) is lower than that of its presumed pathological correlate, cerebral amyloid angiopathy. We examined 18 patients with early AD or mild cognitive impairment (MCI) and 18 non-demented controls with ultra-high field strength 7Tesla MRI, to assess if the actual prevalence of microbleeds could be higher than is currently reported. One or more microbleeds were visualized in 78% of the MCI/AD patients and in 44% of the controls (p = 0.04). 7Tesla MRI shows that presence of microbleeds may be the rule, rather than exception in patients with MCI/AD.

引用

页码：259 / 263

页数：5

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