ENHANCED ANTIVIRAL ACTIVITY OF ACYCLOVIR LOADED INTO NANOPARTICLES

被引：29

作者：

Cavalli, Roberta ^{[1
]}

Donalisio, Manuela ^{[2
]}

Bisazza, Agnese ^{[1
]}

Civra, Andrea ^{[2
]}

Ranucci, Elisabetta ^{[3
]}

Ferruti, Paolo ^{[3
]}

Lembo, David ^{[2
]}

机构：

[1] Univ Turin, Dipartimento Sci & Tecnol Farmaco, Turin, Italy

[2] Univ Turin, Dipartimento Sci Clin & Biol, Turin, Italy

[3] Univ Milan, Dipartimento Chm Organ & Ind, Milan, Italy

来源：

NANOMEDICINE: INFECTIOUS DISEASES, IMMUNOTHERAPY, DIAGNOSTICS, ANTIFIBROTICS, TOXICOLOGY AND GENE MEDICINE | 2012年 / 509卷

关键词：

POLYMER NANOPARTICLES; DELIVERY-SYSTEMS; PARAMETERS; CLATHRIN; PATHWAY; CELLS;

D O I：

10.1016/B978-0-12-391858-1.00001-0

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The activity of antivirals can be enhanced by their incorporation in nanoparticulate delivery systems. Peculiar polymeric nanoparticles, based on a beta-cyclodextrin-poly (4-acryloylmorpholine) monoconjugate (beta-CD-PACM), are proposed as acyclovir carriers. The experimental procedure necessary to obtain the acyclovir-loaded nanoparticles using the solvent displacement preparation method will be described in this chapter. Fluorescent labeled nanoparticles are prepared using the same method for cellular trafficking studies. The biocompatibility assays necessary to obtain safe nanoparticles are reported. Section 4 of this chapter describes the assessment of the antiviral activity of the acyclovir-loaded nanoparticles.

引用

页码：1 / 19

页数：19

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