Synthesis, anti-inflammatory and anticancer activity evaluation of some mono- and bis-Schiff's bases

被引：34

作者：

Sondhi, Sham M. ^{[1
]}

Arya, Surbhi ^{[1
]}

Rani, Reshma ^{[1
]}

Kumar, Nikhil ^{[2
]}

Roy, Partha ^{[2
]}

机构：

[1] Indian Inst Technol, Dept Chem, Roorkee 247667, Uttrakhand, India

[2] Indian Inst Technol, Dept Biotechnol, Roorkee 247667, Uttrakhand, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 11期

关键词：

Schiff's bases; Bis-Schiff's bases; Anti-inflammatory; Anticancer evaluation; MICROWAVE-ASSISTED SYNTHESIS; COLON-CANCER; DERIVATIVES; COX-2; DESIGN; ASSAY; ACID;

D O I：

10.1007/s00044-011-9899-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several mono-Schiff's bases (3a-i) and bis-Schiff's bases (5a-f) were synthesized using microwave irradiation technique (3a-h, 5a-c) and by simply grinding at room temperature for a few minutes (3i, 5d-f). All these compounds were characterized by spectroscopic means and elemental analysis. They were screened for anti-inflammatory and anticancer activities (against five human cancer cell lines). Compound 5f exhibited good anti-inflammatory and compounds 3f, 5a-f exhibited good anticancer activity.

引用

页码：3620 / 3628

页数：9

共 30 条

[1]

Aydogan F, 2001, B KOR CHEM SOC, V22, P476

[2]

Bawa S, 2009, INDIAN J CHEM B, V48, P142

[3] Design, synthesis and evaluation of antiinflammatory, analgesic and ulcerogenicity studies of novel S-substituted phenacyl-1,3,4-oxadiazole-2-thiol and Schiff bases of diclofenac acid as nonulcerogenic derivatives [J].

Bhandari, Shashikant V. ;

Bothara, Kailash G. ;

Raut, Mayuresh K. ;

Patil, Ajit A. ;

Sarkate, Aniket P. ;

Mokale, Vinod J. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (04) :1822-1831

[4] COX-2: A molecular target for colorectal cancer prevention [J].

Brown, JR ;

DuBois, RN .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (12) :2840-2855

[5] Inhibition of MIF bioactivity by rational design of pharmacological inhibitors of MIF tautomerase activity [J].

Dios, A ;

Mitchell, RA ;

Aljabari, B ;

Lubetsky, J ;

O'Connor, K ;

Liao, H ;

Senter, PD ;

Manogue, KR ;

Lolis, E ;

Metz, C ;

Bucala, R ;

Callaway, DJE ;

Al-Abed, Y .

JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (12) :2410-2416

[6]

Geronikaki Athina, 2003, Farmaco (Lausanne), V58, P489, DOI 10.1016/S0014-827X(03)00065-X

[7] Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors [J].

Groesch, Sabine ;

Maier, Thorsten Juergen ;

Schiffmann, Susanne ;

Geisslinger, Gerd .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2006, 98 (11) :736-747

[8]

Hadjipavlou-Litina D J, 1998, Drug Des Discov, V15, P199

[9] Cyclooxygenase-2 (cox-2) blockade in the chemoprevention of cancers of the colon, breast, prostate, and lung [J].

Harris R.E. .

Inflammopharmacology, 2009, 17 (2) :55-67

[10]

Harris Randall E, 2007, Subcell Biochem, V42, P193

← 1 2 3 →