Metal complexes of thiosemicarbazones for imaging and therapy

被引：147

作者：

Dilworth, Jonathan R. ^{[1
]}

Hueting, Rebekka ^{[1
]}

机构：

[1] Univ Oxford, Dept Chem, Oxford OX1 3QR, England

来源：

INORGANICA CHIMICA ACTA | 2012年 / 389卷

基金：

英国工程与自然科学研究理事会;

关键词：

Review; Thiosemicarbazones; Complexes; Imaging; Therapy; RIBONUCLEOTIDE REDUCTASE INHIBITOR; POSITRON-EMISSION-TOMOGRAPHY; TRIAPINE 3-AMINOPYRIDINE-2-CARBOXALDEHYDE THIOSEMICARBAZONE; ASSESSING TUMOR HYPOXIA; CRYSTAL-STRUCTURE; IN-VITRO; BIS(THIOSEMICARBAZONE) COMPLEXES; COPPER(II) COMPLEXES; CYTOTOXIC ACTIVITY; ANTITUMOR-ACTIVITY;

D O I：

10.1016/j.ica.2012.02.019

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

This review gives an account of the coordination chemistry of thiosemicarbazone ligands with three (tridentate) or four (tetradentate) potential donor atoms. The syntheses and structures of the ligands complexes are described according to the donor atom combinations and metals involved. The review also covers the biological activities of the ligands and complexes in the context of their applications as therapeutic or diagnostic PET or SPECT imaging agents. Crown Copyright (C) 2012 Published by Elsevier B.V. All rights reserved.

引用

页码：3 / 15

页数：13

共 140 条

[1] Synthesis and characterization of indium(III) complexes with tri- and pentadentate thiosemicarbazones. Crystal and molecular structure of [InCl2(HDAPTSC)]center dot 2DMSO, {O[In(HDAPTSC)(OH)](2))center dot 5MeOH, [InCl2-(APTSC)(MeOH)], [In(APTSC)(2)]PF6 and (H(2)APTSC)][InCl(APTSC)(mnt)]center dot 0.5H(2)O (H(2)DAPTSC equals 2,6-diacetylpyridine-bis(thiosemicarbazone), HAPTSC equals 2-acetylpyridine-thiosemicarbazone, mnt(2-) equals 1,2-dicyanoethene-1,2-dithiolate) [J].