Oxidative Mizoroki-Heck-Type Reaction of Arylsulfonyl Hydrazides for a Highly Regio- and Stereoselective Synthesis of Polysubstituted Alkenes

被引：131
作者：
Yang, Fu-Lai [1 ]
Ma, Xian-Tao [1 ]
Tian, Shi-Kai [1 ,2 ]
机构：
[1] Univ Sci & Technol China, Dept Chem, Joint Lab Green Synthet Chem, Hefei 230026, Anhui, Peoples R China
[2] Chinese Acad Sci, Key Lab Synthet Chem Nat Subst, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2012年 / 18卷 / 06期
基金：
中国国家自然科学基金;
关键词：
alkenes; cross-coupling; Mizoroki-Heck reaction; oxidation; palladium; C-H OLEFINATION; PALLADIUM-CATALYZED REACTION; FUJIWARA-MORITANI REACTIONS; BASE-FREE CONDITIONS; ROOM-TEMPERATURE; CARBOXYLIC-ACIDS; DECARBOXYLATIVE PALLADATION; BOND ACTIVATION; DIAZONIUM SALTS; AROYL CHLORIDES;
D O I：
10.1002/chem.201103671
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A useful source: Arylsulfonyl hydrazides have been identified as synthetically useful aryl sources for the Pd(OAc) 2 catalyzed oxidative Mizoroki-Heck-type reaction under molecular oxygen to provide a convenient access to polysubstituted alkenes in a highly regio- and stereoselective manner (see scheme). The reaction well tolerates various functional groups such as alkoxy, halo, alcohol, carboxylic acid, ester, amide, sulfonamide, and sulfone. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：1582 / 1585
页数：4
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