Changes on brief cognitive instruments over time in Parkinson's disease

被引：72

作者：

Lessig, Stephanie ^{[1
,2
]}

Nie, Dong ^{[3
]}

Xu, Ronghui ^{[3
,4
,5
]}

Corey-Bloom, Jody ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA

[2] VA Med Ctr San Diego, San Diego, CA USA

[3] Univ Calif San Diego, Clin & Translat Res Inst, Biostat Unit, San Diego, CA 92103 USA

[4] Univ Calif San Diego, Dept Family & Prevent Med, San Diego, CA 92103 USA

[5] Univ Calif San Diego, Dept Math, San Diego, CA 92103 USA

来源：

MOVEMENT DISORDERS | 2012年 / 27卷 / 09期

关键词：

Parkinson's Disease; MMSE; MoCA; cognition; MENTAL-STATE-EXAMINATION; SCREENING TOOL; IMPAIRMENT; DEMENTIA; MOCA; DONEPEZIL; MMSE;

D O I：

10.1002/mds.25070

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Two hundred and twenty-one subjects with Parkinson's disease (PD) were examined using the MiniMental Status Examination (MMSE) and Montreal Cognitive Assessment (MoCA), with a subset of these (n = 98) examined on repeat testing up to 3 years. The MoCA was more sensitive in identifying cognitive deficit, specifically in the domains of visuospatial abilities, language, and memory. In longitudinal study, the MMSE changed significantly over time, particularly in patients with disease duration of >10 years. The MoCA, however, did not change significantly, even when subjects were stratified by age, MMSE score, and disease duration. This suggests that the MoCA may be more sensitive for detecting early cognitive change in PD, but that the MMSE, and not the MoCA, may be better for tracking cognitive decline. (c) 2012 Movement Disorder Society

引用

页码：1125 / 1128

页数：4

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