Production of biologically active human lymphotactin (XCL1) by Lactococcus lactis

被引：8
|
作者：
Zavala-Flores, Laura M. [2 ]
Villatoro-Hernandez, Julio [2 ]
Gamez-Escobedo, Anali [3 ]
Franco-Molina, Moises [3 ]
Rangel-Colmenero, Blanca R. [2 ]
Villanueva-Olivo, Arnulfo [2 ]
Gutierrez-Puente, Yolanda [4 ]
Montes de Oca-Luna, Roberto [2 ]
Valdes-Flores, Jesus [5 ]
Saucedo-Cardenas, Odila [1 ,2 ]
机构：
[1] IMSS, Ctr Invest Biomed Noreste, Div Genet, Monterrey 64720, NL, Mexico
[2] UANL, Fac Med, Dept Histol, Monterrey, NL, Mexico
[3] UANL, Dept Microbiol & Immunol, San Nicolas De Los Garza, NL, Mexico
[4] UANL, Dept Bioquim, Fac Ciencias Biol, San Nicolas De Los Garza, NL, Mexico
[5] CINVESTAV, Dept Bioquim, Mexico City 07360, DF, Mexico
来源：
BIOTECHNOLOGY LETTERS | 2009年 / 31卷 / 02期
关键词：
Biological activity; Lactococcus lactis; Lymphotactin; Secretion; CD8(+) T-CELLS; MUCOSAL DELIVERY; ACID BACTERIA; EXPRESSION;
D O I：
10.1007/s10529-008-9855-6
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Lymphotactin-XCL1 is a chemokine produced mainly by activated CD8+ T-cells and directs migration of CD4+ and CD8+ lymphocytes and natural killer (NK) cells. We expressed human lymphotactin (LTN) by the lactic-acid bacterium Lactococcus lactis. Biological activity of LTN was confirmed by chemo-attraction of human T-cells by chemotaxis demonstrating, for the first time, how this chemokine secreted by a food-grade prokaryote retains biological activity and chemoattracts T lymphocytes. This strain thus represents a feasible well-tolerated vector to deliver active LTN at a mucosal level.
引用
收藏
页码：215 / 220
页数：6
相关论文
共 50 条
  • [31] Influence of Culture Conditions and Medium Compositions on the Production of Bacteriocin-Like Inhibitory Substances by Lactococcus lactis Gh1
    Jawan, Roslina
    Abbasiliasi, Sahar
    Tan, Joo Shun
    Mustafa, Shuhaimi
    Halim, Murni
    Ariff, Arbakariya B.
    MICROORGANISMS, 2020, 8 (10) : 1 - 14
  • [32] Unlocking the Potential of Lactococcus lactis subsp. lactis BIONCL17752 strain on Fumonisin B1 production by Fusarium verticillioides
    Navale, Vishwambar D.
    Vamkudoth, Koteswara Rao
    FOOD CONTROL, 2025, 168
  • [33] Production of pediocin PA-1, and coproduction of nisin A and pediocin PA-1, by wild Lactococcus lactis strains of dairy origin
    Reviriego, C
    Fernández, A
    Horn, N
    Rodríguez, E
    Marín, ML
    Fernández, L
    Rodríguez, JM
    INTERNATIONAL DAIRY JOURNAL, 2005, 15 (01) : 45 - 49
  • [34] Extracellular production of an intact and biologically active human growth hormone by the Bacillus brevis system
    Kajino, T
    Saito, Y
    Asami, O
    Yamada, Y
    Hirai, M
    Udata, S
    JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 1997, 19 (04): : 227 - 231
  • [35] Production of biologically active human granulocyte colony stimulating factor in the milk of transgenic goat
    Ho Ko J.
    Lee C.-S.
    Kim K.H.
    Pang M.-G.
    Koo J.S.
    Fang N.
    Koo D.-B.
    Oh K.B.
    Youn W.-S.
    Zheng G.D.
    Park J.S.
    Kim S.J.
    Han Y.-M.
    Choi I.Y.
    Lim J.
    Shin S.T.
    Jin S.W.
    Lee K.-K.
    Yoo O.J.
    Transgenic Research, 2000, 9 (3) : 215 - 222
  • [36] Production of biologically active human granulocyte colony stimulating factor in the milk of transgenic goat
    Ko, JH
    Lee, CS
    Kim, KH
    Pang, MG
    Koo, JS
    Fang, NZ
    Koo, DB
    Oh, KB
    Youn, WS
    Zheng, GD
    Park, JS
    Kim, SJ
    Han, YM
    Choi, IY
    Lim, J
    Shin, ST
    Jin, SW
    Lee, KK
    Yoo, OJ
    TRANSGENIC RESEARCH, 2000, 9 (03) : 215 - 222
  • [37] Successful production of human epidermal growth factor in tobacco chloroplasts in a biologically active conformation
    Wang, Yunpeng
    Fan, Jieying
    Ahamd, Niaz
    Xin, Wen
    Wei, Zhengyi
    Xing, Shaochen
    GROWTH FACTORS, 2023, 41 (01) : 20 - 31
  • [38] Influence of Environmental Factors on Bacteriocin Production by Human Isolates of Lactococcus lactis MM19 and Pediococcus acidilactici MM33
    Turgis, Melanie
    Khanh Dang Vu
    Millette, Mathieu
    Dupont, Claude
    Lacroix, Monique
    PROBIOTICS AND ANTIMICROBIAL PROTEINS, 2016, 8 (01) : 53 - 59
  • [39] Autocrine production of biologically active hepatocyte growth factor (HGF) by injured human skin
    Nayeri, F
    Xu, JJ
    Abdiu, A
    Nayeri, T
    Aili, D
    Liedberg, B
    Carlsson, U
    JOURNAL OF DERMATOLOGICAL SCIENCE, 2006, 43 (01) : 49 - 56
  • [40] Short communication:: Immunity gene pedB enhances production of pediocin PA-1 in naturally resistant Lactococcus lactis strains
    Arques, J. L.
    Rodriguez, J. M.
    Gasson, M. J.
    Horn, N.
    JOURNAL OF DAIRY SCIENCE, 2008, 91 (07) : 2591 - 2594
12345