Production of biologically active human lymphotactin (XCL1) by Lactococcus lactis

被引：8
|
作者：
Zavala-Flores, Laura M. [2 ]
Villatoro-Hernandez, Julio [2 ]
Gamez-Escobedo, Anali [3 ]
Franco-Molina, Moises [3 ]
Rangel-Colmenero, Blanca R. [2 ]
Villanueva-Olivo, Arnulfo [2 ]
Gutierrez-Puente, Yolanda [4 ]
Montes de Oca-Luna, Roberto [2 ]
Valdes-Flores, Jesus [5 ]
Saucedo-Cardenas, Odila [1 ,2 ]
机构：
[1] IMSS, Ctr Invest Biomed Noreste, Div Genet, Monterrey 64720, NL, Mexico
[2] UANL, Fac Med, Dept Histol, Monterrey, NL, Mexico
[3] UANL, Dept Microbiol & Immunol, San Nicolas De Los Garza, NL, Mexico
[4] UANL, Dept Bioquim, Fac Ciencias Biol, San Nicolas De Los Garza, NL, Mexico
[5] CINVESTAV, Dept Bioquim, Mexico City 07360, DF, Mexico
来源：
BIOTECHNOLOGY LETTERS | 2009年 / 31卷 / 02期
关键词：
Biological activity; Lactococcus lactis; Lymphotactin; Secretion; CD8(+) T-CELLS; MUCOSAL DELIVERY; ACID BACTERIA; EXPRESSION;
D O I：
10.1007/s10529-008-9855-6
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Lymphotactin-XCL1 is a chemokine produced mainly by activated CD8+ T-cells and directs migration of CD4+ and CD8+ lymphocytes and natural killer (NK) cells. We expressed human lymphotactin (LTN) by the lactic-acid bacterium Lactococcus lactis. Biological activity of LTN was confirmed by chemo-attraction of human T-cells by chemotaxis demonstrating, for the first time, how this chemokine secreted by a food-grade prokaryote retains biological activity and chemoattracts T lymphocytes. This strain thus represents a feasible well-tolerated vector to deliver active LTN at a mucosal level.
引用
收藏
页码：215 / 220
页数：6
相关论文
共 50 条
  • [21] Secretion of biologically active interferon-gamma inducible protein-10 (IP-10) by Lactococcus lactis
    Julio Villatoro-Hernandez
    Maria J Loera-Arias
    Anali Gamez-Escobedo
    Moises Franco-Molina
    Jorge G Gomez-Gutierrez
    Humberto Rodriguez-Rocha
    Yolanda Gutierrez-Puente
    Odila Saucedo-Cardenas
    Jesus Valdes-Flores
    Roberto Montes-de-Oca-Luna
    Microbial Cell Factories, 7
  • [22] Optimization of lactic acid production by immobilized Lactococcus lactis IO-1
    Sirisansaneeyakul, Sarote
    Luangpipat, Tiyaporn
    Vanichsriratana, Wirat
    Srinophakun, Thongchai
    Chen, Henry Ho-Hsien
    Chisti, Yusuf
    JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 2007, 34 (05) : 381 - 391
  • [23] Biosynthetic production of nisin Z by immobilized Lactococcus lactis IO-1
    Sonomoto, K
    Chinachoti, N
    Endo, N
    Ishizaki, A
    JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2000, 10 (1-3) : 325 - 334
  • [24] Production of Recombinant Protein of Salsola Kali (Sal k1) Pollen Allergen in Lactococcus Lactis
    Ghasemi, Ziba
    Varasteh, Abdol-Reza
    Moghadam, Malihe
    Sedghi, Farnaz
    Jabbariazad, Farahzad
    Sankian, Mojtaba
    IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY, 2018, 17 (02) : 134 - 143
  • [25] Production of Brucella melitensis Omp16 protein fused to the human interleukin 2 in Lactococcus lactis MG1363 toward developing a Lactococcus-based vaccine against brucellosis
    Rezaei, Marzieh
    Khorasgani, Mohammad Rabbani
    Esfahani, Sayyed Hamid Zarkesh
    Emamzadeh, Rahman
    Abtahi, Hamid
    CANADIAN JOURNAL OF MICROBIOLOGY, 2020, 66 (01) : 39 - 45
  • [26] Nisin-Inducible Secretion of a Biologically Active Single-Chain Insulin Analog by Lactococcus lactis NZ9000
    Ng, Daphne T. W.
    Sarkar, Casim A.
    BIOTECHNOLOGY AND BIOENGINEERING, 2011, 108 (08) : 1987 - 1996
  • [27] Production, active staining and gas chromatography assay analysis of recombinant aminopeptidase P from Lactococcus lactis ssp lactis DSM 20481
    Stressler, Timo
    Eisele, Thomas
    Schlayer, Michael
    Fischer, Lutz
    AMB EXPRESS, 2012, 2 : 1 - 12
  • [28] Secretion of human interferon-β 1b by recombinant Lactococcus lactis
    Zhong Zhuang
    Zhi-gang Wu
    Min Chen
    Peng George Wang
    Biotechnology Letters, 2008, 30
  • [29] Secretion of biologically active pancreatitis-associated protein I ( PAP) by genetically modified dairy Lactococcus lactis NZ9000 in the prevention of intestinal mucositis
    Carvalho, Rodrigo D.
    Breyner, Natalia
    Menezes-Garcia, Zelia
    Rodrigues, Nubia M.
    Lemos, Luisa
    Maioli, Tatiane U.
    Souza, Danielle da Gloria
    Carmona, Denise
    de Faria, Ana M. C.
    Langella, Philippe
    Chatel, Jean-Marc
    Bermudez-Humaran, Luis G.
    Figueiredo, Henrique C. P.
    Azevedo, Vasco
    de Azevedo, Marcela S.
    MICROBIAL CELL FACTORIES, 2017, 16
  • [30] Nisin Z production by Lactococcus lactis IO-1 using xylose as a carbon source
    Chinachoti, N
    Matsusaki, H
    Sonomoto, K
    Ishizaki, A
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1998, 62 (05) : 1022 - 1024
12345