Production of biologically active human lymphotactin (XCL1) by Lactococcus lactis

被引：8
|
作者：
Zavala-Flores, Laura M. [2 ]
Villatoro-Hernandez, Julio [2 ]
Gamez-Escobedo, Anali [3 ]
Franco-Molina, Moises [3 ]
Rangel-Colmenero, Blanca R. [2 ]
Villanueva-Olivo, Arnulfo [2 ]
Gutierrez-Puente, Yolanda [4 ]
Montes de Oca-Luna, Roberto [2 ]
Valdes-Flores, Jesus [5 ]
Saucedo-Cardenas, Odila [1 ,2 ]
机构：
[1] IMSS, Ctr Invest Biomed Noreste, Div Genet, Monterrey 64720, NL, Mexico
[2] UANL, Fac Med, Dept Histol, Monterrey, NL, Mexico
[3] UANL, Dept Microbiol & Immunol, San Nicolas De Los Garza, NL, Mexico
[4] UANL, Dept Bioquim, Fac Ciencias Biol, San Nicolas De Los Garza, NL, Mexico
[5] CINVESTAV, Dept Bioquim, Mexico City 07360, DF, Mexico
来源：
BIOTECHNOLOGY LETTERS | 2009年 / 31卷 / 02期
关键词：
Biological activity; Lactococcus lactis; Lymphotactin; Secretion; CD8(+) T-CELLS; MUCOSAL DELIVERY; ACID BACTERIA; EXPRESSION;
D O I：
10.1007/s10529-008-9855-6
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Lymphotactin-XCL1 is a chemokine produced mainly by activated CD8+ T-cells and directs migration of CD4+ and CD8+ lymphocytes and natural killer (NK) cells. We expressed human lymphotactin (LTN) by the lactic-acid bacterium Lactococcus lactis. Biological activity of LTN was confirmed by chemo-attraction of human T-cells by chemotaxis demonstrating, for the first time, how this chemokine secreted by a food-grade prokaryote retains biological activity and chemoattracts T lymphocytes. This strain thus represents a feasible well-tolerated vector to deliver active LTN at a mucosal level.
引用
收藏
页码：215 / 220
页数：6
相关论文
共 50 条
  • [1] Production of biologically active human lymphotactin (XCL1) by Lactococcus lactis
    Laura M. Zavala-Flores
    Julio Villatoro-Hernandez
    Anali Gamez-Escobedo
    Moisés Franco-Molina
    Blanca R. Rangel-Colmenero
    Arnulfo Villanueva-Olivo
    Yolanda Gutierrez-Puente
    Roberto Montes de Oca-Luna
    Jesús Valdés-Flores
    Odila Saucedo-Cardenas
    Biotechnology Letters, 2009, 31 : 215 - 220
  • [2] Glycosylated recombinant human XCL1/lymphotactin exhibits enhanced biologic activity
    Dong, C
    Chua, A
    Ganguly, S
    Krensky, AM
    Clayberger, C
    JOURNAL OF IMMUNOLOGICAL METHODS, 2005, 302 (1-2) : 136 - 144
  • [3] Secretion of biologically active human interleukin 22 (IL-22) by Lactococcus lactis
    Loera-Arias, Maria J.
    Villatoro-Hernandez, Julio
    Parga-Castillo, Miguel A.
    Salcido-Montenegro, Alejandro
    Barboza-Quintana, Oralia
    Munoz-Maldonado, Gerardo E.
    Montes-de-Oca-Luna, Roberto
    Saucedo-Cardenas, Odila
    BIOTECHNOLOGY LETTERS, 2014, 36 (12) : 2489 - 2494
  • [4] Blockade of XCL1/Lymphotactin Ameliorates Severity of Periprosthetic Osteolysis Triggered by Polyethylene-Particles
    Tian, Yuan
    Terkawi, Mohamad Alaa
    Onodera, Tomohiro
    Alhasan, Hend
    Matsumae, Gen
    Takahashi, Daisuke
    Hamasaki, Masanari
    Ebata, Taku
    Aly, Mahmoud Khamis
    Kida, Hiroaki
    Shimizu, Tomohiro
    Uetsuki, Keita
    Kadoya, Ken
    Iwasaki, Norimasa
    FRONTIERS IN IMMUNOLOGY, 2020, 11 : 1720
  • [5] A Novel Role for Lymphotactin (XCL1) Signaling in the Nervous System: XCL1 Acts via its Receptor XCR1 to Increase Trigeminal Neuronal Excitability
    Bird, Emma V.
    Iannitti, Tommaso
    Christmas, Claire R.
    Obara, Ilona
    Andreev, Veselin I.
    King, Anne E.
    Boissonade, Fiona M.
    NEUROSCIENCE, 2018, 379 : 334 - 349
  • [6] Expression of biologically active murine interleukin-18 in Lactococcus lactis
    Feizollahzadeh, Sadegh
    Khanahmad, Hossein
    Rahimmanesh, Ilnaz
    Ganjalikhani-hakemi, Mazdak
    Andalib, Alireza
    Sanei, Mohammad Hossein
    Rezaei, Abbas
    FEMS MICROBIOLOGY LETTERS, 2016, 363 (21)
  • [7] Secretion of biologically active murine interleukin-10 by Lactococcus lactis
    Schotte, L
    Steidler, L
    Vandekerckhove, J
    Remaut, E
    ENZYME AND MICROBIAL TECHNOLOGY, 2000, 27 (10) : 761 - 765
  • [8] A Novel α9 Integrin Ligand, XCL1/Lymphotactin, Is Involved in the Development of Murine Models of Autoimmune Diseases
    Matsumoto, Naoki
    Kon, Shigeyuki
    Nakatsuru, Takuya
    Miyashita, Tomoe
    Inui, Kyosuke
    Saitoh, Kodai
    Kitai, Yuichi
    Muromoto, Ryuta
    Kashiwakura, Jun-ichi
    Uede, Toshimitsu
    Matsuda, Tadashi
    JOURNAL OF IMMUNOLOGY, 2017, 199 (01) : 82 - 90
  • [9] Production of human growth hormone by Lactococcus lactis
    Margolles, Abelardo
    Antonio Moreno, Jose
    Ruiz, Lorena
    Marelli, Belkis
    Magni, Christian
    de los Reyes-Gavilan, Clara G.
    Ruas-Madiedo, Patricia
    JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 2010, 109 (04) : 322 - 324
  • [10] The systemic exercise-released chemokine lymphotactin/XCL1 modulates in vitro adult hippocampal precursor cell proliferation and neuronal differentiation
    Leiter, Odette
    Bernas, Stefanie N.
    Seidemann, Suse
    Overall, Rupert W.
    Horenburg, Cindy
    Kowal, Susann
    Kempermann, Gerd
    Walker, Tara L.
    SCIENTIFIC REPORTS, 2019, 9 (1)
12345