AMP-activated protein kinase: A master switch in glucose and lipid metabolism

被引：99
作者：
Hardie, DG [1 ]
机构：
[1] Univ Dundee, Div Mol Physiol, Wellcome Trust Bioctr, Dundee DD1 5EH, Scotland
来源：
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS | 2004年 / 5卷 / 02期
基金：
英国惠康基金; 英国医学研究理事会;
关键词：
AMP-activated protein kinase; glucose uptake; Type; 2; diabetes; obesity; metabolic syndrome;
D O I：
10.1023/B:REMD.0000021433.63915.bb
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
[No abstract available]
引用
收藏
页码：119 / 125
页数：7
相关论文
共 64 条
  • [1] Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO
  • [2] 2-S
  • [3] Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy
    Arad, M
    Benson, DW
    Perez-Atayde, AR
    McKenna, WJ
    Sparks, EA
    Kanter, RJ
    McGarry, K
    Seidman, JG
    Seidman, CE
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (03) : 357 - 362
  • [4] Effect of 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats
    Bergeron, R
    Previs, SF
    Cline, GW
    Perret, P
    Russell, RR
    Young, LH
    Shulman, GI
    [J]. DIABETES, 2001, 50 (05) : 1076 - 1082
  • [5] Mutations in the γ2 subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy:: evidence for the central role of energy compromise in disease pathogenesis
    Blair, E
    Redwood, C
    Ashrafian, H
    Oliveira, M
    Broxholme, J
    Kerr, B
    Salmon, A
    Östman-Smith, I
    Watkins, H
    [J]. HUMAN MOLECULAR GENETICS, 2001, 10 (11) : 1215 - 1220
  • [6] Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome
    Buhl, ES
    Jessen, N
    Pold, R
    Ledet, T
    Flyvbjerg, A
    Pedersen, SB
    Pedersen, O
    Schmitz, O
    Lund, S
    [J]. DIABETES, 2002, 51 (07) : 2199 - 2206
  • [7] Liver AMP-activated protein kinase and acetyl-CoA carboxylase during and after exercise
    Carlson, CL
    Winder, WW
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 1999, 86 (02) : 669 - 674
  • [8] Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding
    Cheung, PCF
    Salt, IP
    Davies, SP
    Hardie, DG
    Carling, D
    [J]. BIOCHEMICAL JOURNAL, 2000, 346 : 659 - 669
  • [9] CORTON JM, 1995, EUR J BIOCHEM, V229, P558, DOI 10.1111/j.1432-1033.1995.tb20498.x
  • [10] Physiological role of AMP-activated protein kinase in the heart: graded activation during exercise
    Coven, DL
    Hu, XY
    Cong, L
    Bergeron, R
    Shulman, GI
    Hardie, DG
    Young, LH
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2003, 285 (03): : E629 - E636
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