ACTN3 R577X polymorphism and team-sport performance: A study involving three European cohorts

被引：45

作者：

Eynon, Nir ^{[1
,2
]}

Banting, Lauren K. ^{[2
]}

Ruiz, Jonatan R. ^{[3
]}

Cieszczyk, Pawel ^{[4
]}

Dyatlov, Dmitry A. ^{[5
]}

Maciejewska-Karlowska, Agnieszka ^{[6
]}

Sawczuk, Marek ^{[6
]}

Pushkarev, Vladimir P. ^{[5
]}

Kulikov, Leonid M. ^{[5
]}

Pushkarev, Evgeny D. ^{[5
]}

Femia, Pedro ^{[7
]}

Stepto, Nigel K. ^{[1
,2
]}

Bishop, David J. ^{[1
,2
]}

Lucia, Alejandro ^{[8
]}

机构：

[1] Victoria Univ, Sch Sport & Exercise Sci, Melbourne, Vic 8001, Australia

[2] Victoria Univ, Inst Sport Exercise & Act Living, Melbourne, Vic 8001, Australia

[3] Univ Granada, Sch Sport Sci, Dept Phys Educ & Sport, E-18071 Granada, Spain

[4] Acad Phys Educ & Sport Gdansk, Dept Tourism & Recreat, Gdansk, Poland

[5] Ural State Univ Phys Culture, Ekaterinburg, Russia

[6] Univ Szczecin, Dept Phys Culture & Hlth Promot, PL-70453 Szczecin, Poland

[7] Univ Granada, Sch Med, Dept Biostat, E-18071 Granada, Spain

[8] Univ Europea Madrid, Madrid, Spain

来源：

JOURNAL OF SCIENCE AND MEDICINE IN SPORT | 2014年 / 17卷 / 01期

关键词：

ACTN3; Alpha-actinin; 3; Exercise; Athletic performance; Genes; REPEATED-SPRINT ABILITY; ALPHA-ACTININ-3; DEFICIENCY; ATHLETIC PERFORMANCE; MUSCLE METABOLISM; GENOTYPE; ASSOCIATION; GENE; STRENGTH; PLAYERS; ALLELE;

D O I：

10.1016/j.jsams.2013.02.005

中图分类号：

G8 [体育];

学科分类号：

04 ; 0403 ;

摘要：

Objectives: To determine the association between the alpha-actinin-3 (ACTN3) R577X polymorphism and elite team-sport athletic status in three cohorts of European team-sport athletes. Design: We compared the genotype and allele frequencies of the ACTN3 R577X (rs1815739) polymorphisms between team-sport athletes (n = 205), endurance athletes (n = 305), sprint/power athletes (n = 378), and non-athletic controls (n = 568) from Poland, Russia and Spain; all participants were unrelated European men. Methods: Genomic DNA was extracted from either buccal epithelium or peripheral blood using a standard protocol. Genotyping was performed using several methods, and the results were replicated following recent recommendations for genotype-phenotype association studies. Results: Genotype distributions of all control and athletic groups met Hardy-Weinberg equilibrium (all p >0.05). Team-sport athletes were less likely to have the 577RR genotype compared to the 577XX genotype than sprint/power athletes [odds ratio: 0.58, 95% confidence interval: 0.34-0.39, p = 0.0451. However, the ACTN3 R577X polymorphism was not associated with team-sports athletic status, compared to endurance athletes and non-athletic controls. Furthermore, no association was observed for any of the genotypes with respect to the level of competition (elite vs. national level). Conclusions: The ACTN3 R577X polymorphism was not associated with team-sport athletic status, compared to endurance athletes and non-athletic controls, and the observation that the 577RR genotype is overrepresented in power/sprint athletes compared with team-sport athletes needs to be confirmed in future studies. (C) 2013 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

引用

页码：102 / 106

页数：5

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