Epidemiologically linked transmission of HIV-1 illustrates the impact of host genetics on virological outcome

被引：2

作者：

Streeck, Hendrik ^{[1
]}

Jessen, Heiko ^{[2
]}

Kuecherer, Claudia ^{[3
]}

Li, Bin ^{[1
]}

Jessen, Arne B. ^{[2
]}

Dupke, Stephan ^{[4
]}

Baumgarten, Axel ^{[4
]}

Stahmer, Ingrid ^{[5
]}

van Lunzen, Jan ^{[5
]}

Altfeld, Marcus ^{[1
]}

Walker, Bruce D. ^{[1
,6
,7
]}

Allen, Todd M. ^{[1
]}

机构：

[1] Harvard Univ, Partners AIDS Res Ctr, Div Infect Dis, Massachusetts Gen Hosp,Med Sch, Charlestown, MA USA

[2] HIV Clin Dres Jessen, Berlin, Germany

[3] Robert Koch Inst, D-1000 Berlin, Germany

[4] HIV Clin Baumgarten, Berlin, Germany

[5] Univ Med Ctr Hamburg Eppendorf, Infect Dis Unit, Hamburg, Germany

[6] Univ Hamburg, Heinrich Pette Inst Expt Virol & Immunol, D-2000 Hamburg, Germany

[7] Howard Hughes Med Inst, Chevy Chase, MD USA

来源：

AIDS | 2009年 / 23卷 / 02期

关键词：

IMMUNODEFICIENCY-VIRUS-INFECTION; T-CELL RESPONSES; ANTIRETROVIRAL THERAPY; DISEASE PROGRESSION; TYPE-1; INFECTION; VIRAL CONTROL; ESCAPE; DISCONTINUATION; SELECTION; MUTATION;

D O I：

10.1097/QAD.0b013e328315a78b

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The diversity of HIV-1 and human genetics complicates our ability to determine the impact of treatment during primary HIV-1 infection on disease outcome. Here, we show, in a small group infected with virtually identical HIV-1 strains and treated during primary HIV-1 infection, that patients expressing protective human leucocyte antigen alleles had lower viral loads following treatment discontinuation. These data suggest that genetic factors play an important role in the outcome of HIV-1 infection despite early therapy.

引用

页码：259 / 262

页数：4

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