Epidemiologically linked transmission of HIV-1 illustrates the impact of host genetics on virological outcome

被引：2
作者：
Streeck, Hendrik [1 ]
Jessen, Heiko [2 ]
Kuecherer, Claudia [3 ]
Li, Bin [1 ]
Jessen, Arne B. [2 ]
Dupke, Stephan [4 ]
Baumgarten, Axel [4 ]
Stahmer, Ingrid [5 ]
van Lunzen, Jan [5 ]
Altfeld, Marcus [1 ]
Walker, Bruce D. [1 ,6 ,7 ]
Allen, Todd M. [1 ]
机构：
[1] Harvard Univ, Partners AIDS Res Ctr, Div Infect Dis, Massachusetts Gen Hosp,Med Sch, Charlestown, MA USA
[2] HIV Clin Dres Jessen, Berlin, Germany
[3] Robert Koch Inst, D-1000 Berlin, Germany
[4] HIV Clin Baumgarten, Berlin, Germany
[5] Univ Med Ctr Hamburg Eppendorf, Infect Dis Unit, Hamburg, Germany
[6] Univ Hamburg, Heinrich Pette Inst Expt Virol & Immunol, D-2000 Hamburg, Germany
[7] Howard Hughes Med Inst, Chevy Chase, MD USA
来源：
AIDS | 2009年 / 23卷 / 02期
关键词：
IMMUNODEFICIENCY-VIRUS-INFECTION; T-CELL RESPONSES; ANTIRETROVIRAL THERAPY; DISEASE PROGRESSION; TYPE-1; INFECTION; VIRAL CONTROL; ESCAPE; DISCONTINUATION; SELECTION; MUTATION;
D O I：
10.1097/QAD.0b013e328315a78b
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The diversity of HIV-1 and human genetics complicates our ability to determine the impact of treatment during primary HIV-1 infection on disease outcome. Here, we show, in a small group infected with virtually identical HIV-1 strains and treated during primary HIV-1 infection, that patients expressing protective human leucocyte antigen alleles had lower viral loads following treatment discontinuation. These data suggest that genetic factors play an important role in the outcome of HIV-1 infection despite early therapy.
引用
收藏
页码：259 / 262
页数：4
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