A Role for Angiopoietin-2 in Organ-Specific Metastasis

被引：20

作者：

Rigamonti, Nicolo ^{[1
]}

De Palma, Michele ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Swiss Inst Expt Canc Res ISREC, Sch Life Sci, Swiss Fed Inst Technol Lausanne, CH-1015 Lausanne, Switzerland

来源：

CELL REPORTS | 2013年 / 4卷 / 04期

关键词：

ENDOTHELIAL-CELLS; TUMOR-GROWTH; ANGIOGENESIS;

D O I：

10.1016/j.celrep.2013.07.034

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Angiopoietin-2 (ANG2/ANGPT2) has recently emerged as a promising target for the inhibition of tumor metastasis. In this issue of Cell Reports, Minami et al. show that the calcineurin-NFAT pathway promotes pulmonary tumor metastasis by inducing ANG2 in the lung endothelium.

引用

收藏

页码：621 / 623

页数：3

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