Stem Cells and Tissue-Engineered Skin

被引：40
|
作者：
Charruyer, A. [1 ]
Ghadially, R. [1 ]
机构：
[1] Univ Calif San Francisco, Vet Adm Med Ctr, Dept Dermatol, San Francisco, CA 94121 USA
来源：
SKIN PHARMACOLOGY AND PHYSIOLOGY | 2009年 / 22卷 / 02期
关键词：
Epidermis; Stem cell; Tissue regeneration; Gene therapy; Stem cell isolation; SIDE POPULATION CELLS; HUMAN EPIDERMAL-KERATINOCYTES; PERIPHERAL-BLOOD FIBROCYTES; LABEL-RETAINING CELLS; HAIR-FOLLICLE; TOPICAL APPLICATION; GENETIC CORRECTION; IN-VIVO; MOUSE; IDENTIFICATION;
D O I：
10.1159/000178864
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Advances in tissue engineering of skin are needed for clinical applications (as in wound healing and gene therapy) for cutaneous and systemic diseases. In this paper we review the use of epidermal stem cells as a source of cells to improve tissue-engineered skin. We discuss the importance and limitations of epidermal stem cell isolation using biomarkers, in quest of a pure stem cell preparation, as well as the culture conditions necessary to maintain this purity as required for a qualitatively superior and long-lasting engineered skin. Finally, we review the advantages of using additional multipotent stem cell sources to functionally and cosmetically optimize the engineered tissue. Copyright (C) 2009 S. Karger AG, Basel
引用
收藏
页码：55 / 62
页数：8
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