X-ray-Induced Singlet Oxygen Activation with Nanoscintillator-Coupled Porphyrins

被引：119

作者：

Bulin, Anne-Laure ^{[1
]}

Truillett, Charles ^{[1
]}

Chouikrat, Rima ^{[2
]}

Lux, Francois ^{[1
]}

Frochot, Celine ^{[2
]}

Amans, David ^{[1
]}

Ledoux, Gilles ^{[1
]}

Tillement, Olivier ^{[1
]}

Perriat, Pascal ^{[3
]}

Barberi-Heyob, Muriel ^{[4
]}

Dujardin, Christophe ^{[1
]}

机构：

[1] Univ Lyon 1, CNRS, Inst Lumiere Mat, UMR5306, F-69622 Villeurbanne, France

[2] Univ Lorraine, CNRS, LRGP, UMR 7274, F-54000 Nancy, France

[3] Univ Lyon, MATEIS, INSA Lyon, UMR CNRS 5510, F-69621 Villeurbanne, France

[4] Univ Lorraine Site CRAN, CRAN, UMR CNRS 7039, Fac Med, F-54505 Vandoeuvre Les Nancy, France

来源：

JOURNAL OF PHYSICAL CHEMISTRY C | 2013年 / 117卷 / 41期

关键词：

PHOTODYNAMIC THERAPY; NANOPARTICLES; RADIATION; LUMINESCENCE; CANCER;

D O I：

10.1021/jp4077189

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Tb2O3 coated with a polysiloxane layer is a biocompatible nanoscintillator that exhibits an appropriate pattern of biodistribution after injection. In this contribution, we combine this nanosystem with porphyrin molecules that are able to generate singlet oxygen, a major cytotoxic agent for photodynamic therapy application. Using time-resolved laser spectroscopy and singlet oxygen probes, we demonstrate this combination is suitable for singlet oxygen generation induced by X-ray and provide a physical study of the energy transfer observed between the nanoscintillator and the porphyrin. Combined with a radiotherapy protocol, the proposed nanohybrid system presents a combination of physical, chemical, and biological properties that make it a good candidate for photodynamic effects in deep tissues.

引用

页码：21583 / 21589

页数：7

共 38 条

[1] Photodynamic Therapy of Cancer: An Update [J].